A8A8X8

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)
KEGG Pathway
iho:Igni_0196
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

443-516 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A8A8X8

Entry ID Method Resolution Chain Position Source
AF-A8A8X8-F1 Predicted AlphaFoldDB

No variants for A8A8X8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A8A8X8

No associated diseases with A8A8X8

4 regional properties for A8A8X8

Type Name Position InterPro Accession
domain DHHA1 domain 771 - 890 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 691 - 734 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 61 - 592 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 55 - 747 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MENEYRLRFF EEEGLKRKRC KVCGSYFWTK GEHEVCGDSP CQEYEFFDVP TKVKLSLRDA
70 80 90 100 110 120
KREFIKFFEE KGHVPVEPRP VVARWRDDLF LTIASIVVFQ PHVTKGLVPP PANPLVIVQP
130 140 150 160 170 180
CIRLEDIDNV GLTLGRHMTG FHMGGHHAFN YPDNWVYWKE ETVKLAYEFF TERIGIPEEL
190 200 210 220 230 240
LNFKESWWEG GGNAGPSFEV TVAGLELATL VFMQYDVVEE NGQKKYVPMK LKVVDTGYGI
250 260 270 280 290 300
ERIAWFTQKT PTAFHAVYGE LLHEFHKRLG VEEPPDELLY ELVRSAGLMD PERPETLERV
310 320 330 340 350 360
YKRASEKLGM RVDEIREIHS RASLVYQVLD HTRTLMWMLA DGIVPSNVGE GYLARLVIRR
370 380 390 400 410 420
TLRALKKLKA DVPLSELLEL QINYWKDDYP RAWKNKDYIL DVVEFEQKKF EETLKKGRNI
430 440 450 460 470 480
VIRLIKKKKQ ITLDDLVELY DSHGIPPDIV SEIAKEMGVR VEVPHNFYSI VASRHQKTVH
490 500 510 520 530 540
KVKGAEEKGK LPPEIIEWAK GFPPTRRLFH EDPYMKEFDA QVIGSNRNYV ILDKTAFYPE
550 560 570 580 590 600
GGGQAADTGV IASGDESYRV VDVQKVGDVI VHVLDRDYSG GKVVVGRIDW ERRYRLMRHH
610 620 630 640 650 660
TGTHLLLGAL RKVLGDHVWQ AGAEKTPEKA RFDFTHHKPL TREEVRKIEE VANKVIDERR
670 680 690 700 710 720
KIRAFTLPRN EAEARYWFSI YQGGVPMSKD IRLVEIEGWD VEACFGTHLS NTGEVGSLKI
730 740 750 760 770 780
ISTRKIQDGV VRVEFVAGTR VAEEAAKMED LIREASEKLS TNPEMLVKRI DALQKELENV
790 800 810 820 830 840
KKTVAEYRKR LVSEYLKAAK ALDGIKYVKL DLRDPELVQE VLRALSSDSP AAVIVDGRVE
850 860 870 880 890 900
LAAPKGVDVG KAVREVVREV GCKGGGKGNR ATVVCESEEK VVELLSKLAA KLTSQPSGRR
G