A7ZE62

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Campylobacter concisus (strain 13826)
KEGG Pathway
cco:CCC13826_0051
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

384-463 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A7ZE62

Entry ID Method Resolution Chain Position Source
AF-A7ZE62-F1 Predicted AlphaFoldDB

No variants for A7ZE62

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A7ZE62

No associated diseases with A7ZE62

4 regional properties for A7ZE62

Type Name Position InterPro Accession
domain DHHA1 domain 702 - 841 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 643 - 686 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 5 - 546 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 1 - 699 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQNLDIRKAY LDFFKSKGHE VVASAPLVPN DATLLFTNAG MVPFKSIFTG EVPRPTPPIR
70 80 90 100 110 120
TSCQTCIRAG GKHNDLDNVG YTARHHTFFE MLGNFSFGEY FKKEAIAYAW EFVTEVLKLP
130 140 150 160 170 180
KDKLYVTVHE SDYEAFEIWS THIAKERIYR FGDHDNFWQM GDTGPCGPCS EIFYDQGAEH
190 200 210 220 230 240
FNTPEDYMGG DGDRFLEIWN LVFMQYERSA DGKLSPLPKP SIDTGMGLER VTAILQGKFS
250 260 270 280 290 300
NYDSTLFMPL ISEVAKLCGK PYVYESGASY RVISDHIRSV TFLLAQGTTF DKEGRGYVLR
310 320 330 340 350 360
RILRRAIRHG YLLGIKEPFM YKLVDKVCEL MGGHYTYLND KKAAVKEQIK LEEERFLATI
370 380 390 400 410 420
ASGLELFESE LKNTKEIFSG EAAFKLYDTF GFPLDLTADM LREKGLKVDE ARFDELMSEQ
430 440 450 460 470 480
KARAKAAWKG SGDKSAKGDF KELLEKFGEN KFIGYEELKS KSKILALLDE EFKNIDGLDA
490 500 510 520 530 540
GKEGWVMFDV TPFYAQSGGQ CGDNGKIVGK ADVLDTEKFH GLNLSLVKTS AALKVGDEVE
550 560 570 580 590 600
LEVGSDRAET ARHHSATHLL HAALRAVVGT HIAQAGSNVE ADRLRFDFSH PKALSGEEIS
610 620 630 640 650 660
KVENLVNEWI VNGANAKTQV MELEEAKKSG AIALFNEKYA DKVRVVSFGD VSKELCGGTH
670 680 690 700 710 720
VKNIDEIGSF FITKESGVSA GVRRIEAVCS RAALNLARSF RAELEELKEE LKSAEPLNAV
730 740 750 760 770 780
KKLKGEIKGL KDKLKNAKNS HALAFLNVND TKLCVASIDS GDIKTLIDEF KNEHEKAAIL
790 800 810 820 830 840
LIQVDEEGKI SLAAGVKNAP IKAGAWVKFA AQILGGNGGG KDDFATAGGK NALAIEDAIR
850
SSVEYARQAL EK