A7Z735

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42) (Bacillus amyloliquefaciens subsp. plantarum)
KEGG Pathway
bay:RBAM_024510
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

144-216 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A7Z735

Entry ID Method Resolution Chain Position Source
AF-A7Z735-F1 Predicted AlphaFoldDB

No variants for A7Z735

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A7Z735

No associated diseases with A7Z735

4 regional properties for A7Z735

Type Name Position InterPro Accession
domain DHHA1 domain 735 - 874 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 655 - 698 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 8 - 557 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 4 - 711 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKHLTSAEVR QMFLDFFKEK GHAVEPSASL VPHEDPSLLW INSGVATLKK YFDGRVVPEN
70 80 90 100 110 120
PRIVNAQKSI RTNDIENVGK TARHHTFFEM LGNFSIGDYF KEEAITWAWE FLTSEKWIGF
130 140 150 160 170 180
DPELLSVTVH PEDEEAYTLW AEKIGVPEER IIRLEGNFWD IGEGPSGPNT EIFYDRGEKY
190 200 210 220 230 240
GNDPSDSELY PGGENDRYLE VWNLVFSEFN HNPDGTYTPL PKKNIDTGMG LERMVSVIQD
250 260 270 280 290 300
VSTNFDTDLF MPIIEATERI SGDAYGKDAV KDTAFKVIAD HIRTVAFAVS DGALPSNEGR
310 320 330 340 350 360
GYVLRRLLRR AVRYAKTLGI SRPFMYELVP TVAGIMDAFY PEVKEKQEFI AKVIKTEEER
370 380 390 400 410 420
FHETLNEGLA ILSDVIKKEK EKGSGIISGK DVFKLYDTYG FPVELTEEYA EDEQMTVDHK
430 440 450 460 470 480
GFEAEMEKQR ERARNARQDV GSMQVQGGAL RDITAESTFV GYSAVKAEAK VIELLHDGQL
490 500 510 520 530 540
ISEAHEGDTV QILLDKTPFY AESGGQIGDR GVLRSEQAVV TIKDVKKAPN GQHVHEGTVD
550 560 570 580 590 600
SGTIQKGASV TAEVEDQMRS GVVKNHTATH LLHQALKDVL GTHVNQAGSL VTENRLRFDF
610 620 630 640 650 660
SHFGQVTKEE LERIEGIVNE KIWESIPVAI DLKPINEAKE MGAMALFGEK YGDIVRVVQV
670 680 690 700 710 720
GDYSLELCGG CHVTNTAEIG LFKIVSESGI GAGTRRIEAV TGKGAYQEMN SQLSLLQHAA
730 740 750 760 770 780
DELKSNVKDV PKRIQSLQAE LKEAQRENES LLSKLGNVEA GAILSKVKDI GGVKVLAEKV
790 800 810 820 830 840
NAKDMNHLRT MVDDLKAKLG SAVIILGAVQ NEKVNLSAGV TKDLIEKGLH AGKMVKQAAE
850 860 870
VCGGGGGGRP DMAQAGGKHP EKLEEALASA VDWIKSVL