A7X2R9

PR
Gene name
gcvPB
Protein name
Probable glycine dehydrogenase (decarboxylating) subunit 2
Names
Glycine cleavage system P-protein subunit 2, Glycine decarboxylase subunit 2, Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Species
Staphylococcus aureus (strain Mu3 / ATCC 700698)
KEGG Pathway
saw:SAHV_1522
EC number
1.4.4.2: With a disulfide as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

137-208 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A7X2R9

Entry ID Method Resolution Chain Position Source
AF-A7X2R9-F1 Predicted AlphaFoldDB

No variants for A7X2R9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A7X2R9

No associated diseases with A7X2R9

3 regional properties for A7X2R9

Type Name Position InterPro Accession
domain Rho GTPase-activating protein domain 27 - 224 IPR000198
domain Ras-like guanine nucleotide exchange factor, N-terminal 236 - 363 IPR000651
domain Ras guanine-nucleotide exchange factors catalytic domain 429 - 664 IPR001895

Functions

Description
EC Number 1.4.4.2 With a disulfide as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
glycine dehydrogenase (decarboxylating) activity Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2.

1 GO annotations of biological process

Name Definition
glycine decarboxylation via glycine cleavage system The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTSKSSPLIF ERSREGRYAY SLPKSDIKTN SVESLLDDKF IRKNKAEFPE VAELDLVRHY
70 80 90 100 110 120
TELSNKNFGV DNGFYPLGSC TMKYNPKINE KVARIPGFSE SHPLQDEDQV QGSLEIIYSL
130 140 150 160 170 180
QEELKEITGM DEVTLQPAAG AHGEWTALMI FKAYHENNGE GHRDEVIVPD SAHGTNPASA
190 200 210 220 230 240
SFAGFKSVTV KSNERGEVDI DDLKRVVNEN TAAIMLTNPN TLGIFEKNIM EIREIVHNAG
250 260 270 280 290 300
GLLYYDGANL NAIMDKVRPG DMGFDAVHLN LHKTFTGPHG GGGPGSGPVG VVKELASYLP
310 320 330 340 350 360
KPMVIKDGDK FKYDNDIKNS IGRVKPFYGN FGIYLRAYTY IRTMGATGLK EVSEAAVLNA
370 380 390 400 410 420
NYIKARLSEH FEIPYKQYCK HEFVLSGVRQ KEFGVRTLDM AKRLLDFGVH PPTIYFPLNV
430 440 450 460 470 480
EEGMMIEPTE TESKETLDYF IDTLISIAEE AKNDPDKVLE APHTTVIDRL DEATAARKPI
LKFENLKQEK