A7TTT5

PR
Gene name
DBP2 (Kpol_165p1)
Protein name
ATP-dependent RNA helicase DBP2
Names
Species
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus)
KEGG Pathway
vpo:Kpol_165p1
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-90 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A7TTT5

Entry ID Method Resolution Chain Position Source
AF-A7TTT5-F1 Predicted AlphaFoldDB

No variants for A7TTT5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A7TTT5

No associated diseases with A7TTT5

5 regional properties for A7TTT5

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 265 - 273 IPR000629
domain Helicase, C-terminal 344 - 441 IPR001650
domain DEAD/DEAH box helicase domain 137 - 308 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 132 - 335 IPR014001
domain RNA helicase, DEAD-box type, Q motif 113 - 141 IPR014014

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

2 GO annotations of biological process

Name Definition
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGYGRDQQYN KSNFNSRGGD FRGDRSSDRN SYNRDRNDNF GQRGGNQGGR SFNQPQELIK
70 80 90 100 110 120
PNWEEELPNL PVFEKNFYQE AESVKARSDQ EINEFRREHE MTITGHDIPK PITSFDEAGF
130 140 150 160 170 180
PDYVLEEVKA EGFEKPTGIQ CQGWPMALSG RDMIGVAATG SGKTLSYCLP GIVHINAQPL
190 200 210 220 230 240
LSPGDGPIVL VLAPTRELAV QIQKECSKFG SSSRIRNSCV YGGVPRGQQI RELSRGAEIV
250 260 270 280 290 300
IATPGRLIDM LEIGKTNLKR VTYLVLDEAD RMLDMGFEPQ IRKIVDQIRP DRQTLMWSAT
310 320 330 340 350 360
WPKEVKQLAH DYLNDPIQVQ IGSLELSASH NITQLVEVVS DFEKRDRLLK HLETASEDKD
370 380 390 400 410 420
SKILVFASTK RTCDEVTKYL REDGWPALAI HGDKDQRERD WVLQEFREGR SPIMVATDVA
430 440
ARGIGMYTNF FFQFCIFFTT N