A7TTL0
Gene name |
CHL1 (Kpol_187p1) |
Protein name |
ATP-dependent DNA helicase CHL1 |
Names |
Chromosome loss protein 1 |
Species |
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus) |
KEGG Pathway |
vpo:Kpol_187p1 |
EC number |
3.6.4.12: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A7TTL0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A7TTL0-F1 | Predicted | AlphaFoldDB |
No variants for A7TTL0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A7TTL0 | |||||
No associated diseases with A7TTL0
5 regional properties for A7TTL0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site | 363 - 372 | IPR002464 |
| domain | Helicase-like, DEXD box c2 type | 3 - 413 | IPR006554 |
| domain | ATP-dependent helicase, C-terminal | 628 - 803 | IPR006555 |
| domain | RAD3-like helicase, DEAD | 214 - 390 | IPR010614 |
| domain | Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type | 1 - 433 | IPR014013 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.12 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA helicase activity | Unwinding of a DNA helix, driven by ATP hydrolysis. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell cycle | The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. |
| cellular response to DNA damage stimulus | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. |
| nucleic acid metabolic process | Any cellular metabolic process involving nucleic acids. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLMSFNHPYQ | PYEIQLQLMQ | CIYGALSSGK | KIAILESPTG | TGKTLSLLCS | SITWLRDNKL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HLLSQNLNNG | GIAINSSIEL | SDDDDFSDDE | PNWVNESYNS | SILDNKLLAL | NDYEKHLDTI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ANKHYKIDKN | LIGNDNNNNK | VKRRKIEHIP | VGFEEDEFLP | QDYISDSEEL | EQTKSEALSN |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EVKALLAKLD | SKSNDEQTTS | TELLQELNPV | KIFFASRTHS | QLKQFASQLK | LPKFKSSFDE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KFVSNERLKY | LPLGSRKQLC | INKSITSKWK | STEAINDACK | ELLQSEKGCP | YHNKNTSNTL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FRDHVFTGVH | DIEDILALGE | SLNVCPYYAT | RDSITSAEII | TLPYQYLLSE | STRDSLNIDL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SNSIVIVDEA | HNLIDTINTI | HSSHISLQEL | KTCQIGLQMY | FAKFKSRLNA | GNRVNLLKLI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KLLDILIEYI | NKNFKKSGQE | ISANEIFNNT | NADTLNIHKL | NQFIKVSKIA | YKIDTYLNSL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SKESDNENNE | ESKNKSTPLL | FKVASFLSSL | TNPNEEGKFF | FEKNKSIKYM | LLEPSQSFKS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| ILDEARCVIL | AGGTMEPISD | FFDNLFPDII | KDKSVTFACD | HVIPDDNLNT | YIIEEPKFEF |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TFDKRQNPEL | VNKHLFQFFI | KLSVNVPPTG | GIVAFFPSYS | YLQFVIDNWR | SNGLFDKLNK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| IREIFYESKN | GSDPLDEYIK | VIEARNPAIL | FAVVGGKLSE | GINFQDDLCR | AVVMTGLPYP |
| 730 | 740 | 750 | 760 | 770 | 780 |
| NVMSGELLIK | KNHIETKILK | NGGSKADVSC | ATKDFFDTIC | MKAVNQSVGR | AIRHIDDYSN |
| 790 | 800 | 810 | 820 | ||
| IYLLDQRYSN | SKIKDKLSQW | VRKRIQPETN | LELIMEKSNR | TFQTKKTSN |