A7TQ73

PR
Gene name
DUS3 (Kpol_483p21)
Protein name
tRNA-dihydrouridine(47) synthase [NAD(P)(+)]
Names
mRNA-dihydrouridine synthase DUS3, tRNA-dihydrouridine synthase 3
Species
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus)
KEGG Pathway
vpo:Kpol_483p21
EC number
1.3.1.89: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-117 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A7TQ73

Entry ID Method Resolution Chain Position Source
AF-A7TQ73-F1 Predicted AlphaFoldDB

No variants for A7TQ73

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A7TQ73

No associated diseases with A7TQ73

4 regional properties for A7TQ73

Type Name Position InterPro Accession
domain Zinc finger, CCCH-type 88 - 122 IPR000571-1
domain Zinc finger, CCCH-type 134 - 164 IPR000571-2
conserved_site tRNA-dihydrouridine synthase, conserved site 378 - 396 IPR018517
domain DUS-like, FMN-binding domain 292 - 572 IPR035587

Functions

Description
EC Number 1.3.1.89 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
flavin adenine dinucleotide binding Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
metal ion binding Binding to a metal ion.
tRNA-dihydrouridine47 synthase activity Catalysis of the reaction: a 5,6-dihydrouracil47 in tRNA + NAD(P) <=> H+ + a uracil47 in tRNA + NAD(P)H.

1 GO annotations of biological process

Name Definition
mRNA processing Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSAEKRELED SGSNGELKRQ DVSFSKGIAH IKAEFIAKSN DNSQFQQAYN DEEIADADRI
70 80 90 100 110 120
GAEGGKNSRK HKKKQRGQNK SRDNRQVKEE KVLCPKYIQG YSEDGESLCQ FGDKCRFVHD
130 140 150 160 170 180
IKEYLSHKKP EIELDQFKIC PVFDALGFCP MGFKCRFMSS HFDKENFKLV KRGTDEERQK
190 200 210 220 230 240
LWSLDHEVNR ITSEEKLSLI KRRFPFTKSN EVLDIIDSIQ QEFRDITAPK VSKEEASEDK
250 260 270 280 290 300
PKDSNEAEVA PQVLQREEEL KKKREHQREL YLKYKDTRYF AQEKKDLDLR RKKIVSPLTT
310 320 330 340 350 360
VGNLPYRRLM RKLGADVTYS EMALAVPLIQ GTNSEWALPK AHSTEIPGFG VQIACSKAWQ
370 380 390 400 410 420
AAKAAEALAK FTPDINEINL NSGCPIDLLY RQGSGSALLD NPARMIRCLN AMNYVSDSIP
430 440 450 460 470 480
ITVKIRTGTR DSHPVADTLV KRLVYETDVA AITLHGRSRQ QRYTRVADWD YVSTVAKSLR
490 500 510 520 530 540
ESEASFLESA EGKESRESKR RIQFVGNGDV NNFEDWHRIL NNDENIDSIM VARGALIKPW
550 560 570 580 590 600
VFEEVDAQQH LDKSSTERLE ILRDYAQFSM EHWGTDEYGI AQCRRFFCEF MSFFHRYIPI
610 620 630 640 650 660
GICERYPVQL NERPPNWVGR DDLETLMGST DARDWIKLSE MFFGKVEESF VFTPKHKSSS
FPSA