A7TK63

PR
Gene name
DBP8 (Kpol_1062p5)
Protein name
ATP-dependent RNA helicase DBP8
Names
Species
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus)
KEGG Pathway
vpo:Kpol_1062p5
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

354-431 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A7TK63

Entry ID Method Resolution Chain Position Source
AF-A7TK63-F1 Predicted AlphaFoldDB

No variants for A7TK63

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A7TK63

No associated diseases with A7TK63

4 regional properties for A7TK63

Type Name Position InterPro Accession
domain Helicase, C-terminal 240 - 389 IPR001650
domain DEAD/DEAH box helicase domain 26 - 196 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 21 - 216 IPR014001
domain RNA helicase, DEAD-box type, Q motif 2 - 30 IPR014014

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

1 GO annotations of biological process

Name Definition
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQDFKSLGLS RWLVESLNAM RITHPTAIQK HCIPEILKGR DCIGGAKTGS GKTIAFAGPM
70 80 90 100 110 120
LSQWSDDPSG MFGVVLTPTR ELAIQIAEQF TALGSSMNIR VCLVVGGESI VKQALELQKK
130 140 150 160 170 180
PHFIIATPGR LAHHILSSGE EVVGGLSRVK YLVLDEADLI LTQTFAADLS TCIAKLPPKQ
190 200 210 220 230 240
KRQTLLFTAT ITDQVRALQN APAQDSKPPL FAYEVENVDN VAVPSTLKLE YLLVPEHVKE
250 260 270 280 290 300
AYLYQLLTCE DYKDSSVIVF VNRTTAAEVL RRTLRSLEVR VASLHSQMPQ SERINSLQRF
310 320 330 340 350 360
RANAARVLIA TDVAARGLDI PTVELVINYD IPQDPDTFIH RSGRTARAGR SGDAISFVTP
370 380 390 400 410 420
RDVSRIEAIE ERINKKMDEC KKVHDTAVIR KALTKVTKAK RESLMDMEKA NFGEKRKTQK
430
KKNLAEKSLR A