A7TG13

PR
Gene name
ATG15 (Kpol_1028p44)
Protein name
Putative lipase ATG15
Names
Autophagy-related protein 15
Species
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus)
KEGG Pathway
vpo:Kpol_1028p44
EC number
3.1.1.3: Carboxylic ester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

461-561 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A7TG13

Entry ID Method Resolution Chain Position Source
AF-A7TG13-F1 Predicted AlphaFoldDB

No variants for A7TG13

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A7TG13

No associated diseases with A7TG13

2 regional properties for A7TG13

Type Name Position InterPro Accession
domain Peptidase M24 140 - 440 IPR000994
binding_site Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site 226 - 242 IPR018349

Functions

Description
EC Number 3.1.1.3 Carboxylic ester hydrolases
Subcellular Localization
  • Endosome, multivesicular body membrane ; Single-pass type II membrane protein
  • Prevacuolar compartment membrane ; Single-pass type II membrane protein
  • From ER, targeted to vacuolar lumen at the MVB vesicles via the Golgi and the prevacuolar compartment (PVC)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
multivesicular body membrane The lipid bilayer surrounding a multivesicular body.

1 GO annotations of molecular function

Name Definition
triglyceride lipase activity Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate.

2 GO annotations of biological process

Name Definition
autophagy The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MISNDYTKFS SKRRSLRYSN RILLLMGTIL LIVVYFYSDI LVDKSIIMFR NENKGQMLSG
70 80 90 100 110 120
SFTLRHIYRH GVDKGHRTQE VLDITKQNED AFGRYFKREL DEFNANAVGL NTDDPLRELW
130 140 150 160 170 180
TSDKQFITDN PFNFKFGLKG NKQILHRMVD RDPSFIEPYL DFARESPDMA AKVTIDWVEG
190 200 210 220 230 240
GEVVVVPDIT DKNTVVSLAL MSSNAYVRLP YTDDWRNVSL PWDSNDTPGY GWESNGIRGH
250 260 270 280 290 300
VFVNDLENIV VISIKGTSAQ GLPGSGEDET TGNDKLNDNL LFSCCCARVS YLWTTVCDCY
310 320 330 340 350 360
LKSYTCDETC LEQAIKEKDH YYQAAMDIYK DTLRQYPHAT IWLTGHSLGG ALASLVGRTY
370 380 390 400 410 420
GLPTVAFESP GELLAAKRLH LPFPPGLPSY DEGIWHIGHT ADPIYMGTCN GASSTCSIAG
430 440 450 460 470 480
YAMETGCHSG KQCVYDVVRD KGWHVNMLNH RIHTVIDGIL TKYDKVATCH EPDPCVDCYN
490 500 510 520 530 540
WNFMPHGKKP KKQTTSSSSE KVDTSTTKSI DRTTITTRTN EKKWHPNPKD PSTTTTDDKT
550 560
LMSSCLHRNW VGICTEYTTF TKRLI