A7NIS8

PR
Gene name
rimO
Protein name
Ribosomal protein S12 methylthiotransferase RimO
Names
S12 MTTase, S12 methylthiotransferase, Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase, Ribosome maturation factor RimO
Species
Roseiflexus castenholzii (strain DSM 13941 / HLO8)
KEGG Pathway
rca:Rcas_1284
EC number
2.8.4.4: Transferring alkylthio groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

88-159 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A7NIS8

Entry ID Method Resolution Chain Position Source
AF-A7NIS8-F1 Predicted AlphaFoldDB

No variants for A7NIS8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A7NIS8

No associated diseases with A7NIS8

7 regional properties for A7NIS8

Type Name Position InterPro Accession
conserved_site MoaA/NifB/PqqE, iron-sulphur binding, conserved site 173 - 184 IPR000385
domain TRAM domain 397 - 466 IPR002792
domain Elp3/MiaA/NifB-like, radical SAM core domain 167 - 386 IPR006638
domain Radical SAM 1 - 465 IPR007197
domain Methylthiotransferase, N-terminal 2 - 115 IPR013848
conserved_site Methylthiotransferase, conserved site 171 - 191 IPR020612
domain RimO, TRAM domain 401 - 465 IPR041582

Functions

Description
EC Number 2.8.4.4 Transferring alkylthio groups
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
metal ion binding Binding to a metal ion.
protein methylthiotransferase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + a

2 GO annotations of biological process

Name Definition
peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid The modification of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid, typical of bacterial ribosomal protein S12.
tRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMKVHIITLG CPKNQVDSEG MSGILAAQGH TLAASADDAD VVIVNTCSFI AAAREETLAV
70 80 90 100 110 120
LRDVAACKTP EQRLVAAGCM AESHRAIVAA TPGVDATLGT REWTRIAEVV ETFQPAATMA
130 140 150 160 170 180
PLNAASAREI IPLTSAGVPS PAPHDLSVPG AYADWRTAPI RRRAVGPSAY LKISDGCNLR
190 200 210 220 230 240
CAFCTIPSFK GDMRSKAIGA ILGEAQELAA AGVKEIVLVA QHLTDYGRDL GLKDGLAILL
250 260 270 280 290 300
DEICAVLPEN VWVRLMYAYP HGIGERLIAT MARHPQICHY LDMPLQHAHP ETLRRMRRPP
310 320 330 340 350 360
DTDRTRRLID DLRAAIPDIA IRSTFIVGFP GETNTEFRAL LAFLEDVQFD RVGVFRYSRE
370 380 390 400 410 420
PGTPAAALPD QLAPRIIERR WHEIMRLQQR ISRERNRRWL GRVVRVLVEG QGQTDDGRML
430 440 450 460 470 480
SVGRSFRDAP EVDGQVLFWG AATPGTFVDV RVTQALDYDL WGDVVGVLDG EERIVKCIQS
VG