A7MQB5

PR
Gene name
ligB
Protein name
DNA ligase B
Names
Polydeoxyribonucleotide synthase [NAD(+)] B
Species
Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
KEGG Pathway
esa:ESA_04079
EC number
6.5.1.2: Forming phosphoric ester bonds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-133 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A7MQB5

Entry ID Method Resolution Chain Position Source
AF-A7MQB5-F1 Predicted AlphaFoldDB

No variants for A7MQB5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A7MQB5

No associated diseases with A7MQB5

5 regional properties for A7MQB5

Type Name Position InterPro Accession
domain NAD-dependent DNA ligase, OB-fold 312 - 383 IPR004150
domain NAD-dependent DNA ligase, adenylation 28 - 282 IPR013839
domain NAD-dependent DNA ligase, N-terminal 28 - 425 IPR013840
active_site NAD-dependent DNA ligase, active site 124 - 153 IPR018239
conserved_site NAD-dependent DNA ligase, conserved site 321 - 336 IPR033136

Functions

Description
EC Number 6.5.1.2 Forming phosphoric ester bonds
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

1 GO annotations of molecular function

Name Definition
DNA ligase (NAD+) activity Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m).

2 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRITIFLLLI ILASAGAYAA CPDWTPQQAQ QEVAALENQL TRWDEAYWLH GENKVSDAVY
70 80 90 100 110 120
DSMRQRLRAW QTCFALPVFN DAPVALAAGR TRHPVAHTGV QKLNDATSLS QWMHGKTDLW
130 140 150 160 170 180
VQPKVDGVAV SLVYRKGKLQ QVISRGDGER GEDWTARARH IPAIPLQVTG ELADSVLQGE
190 200 210 220 230 240
LFLRQTGHRQ QQDGGINARG QVAGAMMRST VSSVLNDLDL FIWAWPDGPK AMEARLSTLA
250 260 270 280 290 300
EGGFPLAQAW SKPVHSVSDV ARLREQWFSE PLPFVTDGVV IREGREPPGK SWRPGEGSWV
310 320 330 340 350 360
VAWKYPPAKQ ITEIKALRFA VGRTGKISVV AQLEPVTLDD KKVSKVSIGS LARWEKLDLA
370 380 390 400 410 420
EGDQVEISLA GQGIPRLDAV IWRPTQRIKP VPPTARFDTL SCLYGTTGCE EQFISRLVWL
430 440 450 460 470 480
SGKHVFDLAG MGEATWRQLS EHHHFEHLFS WLALSVDALK QTPGFSAQRA AQLWHQFNLT
490 500 510 520 530 540
RQQPFQRWVK ALGLPLPARD WQALTDDKWQ QLQARDERSW QTLPGVGAER ARQLVSYIHH
550 560
PDIAALAEWL AAQRIDGFAL P