A7MBI3
Gene name |
L2HGDH |
Protein name |
L-2-hydroxyglutarate dehydrogenase, mitochondrial |
Names |
Duranin |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:514230 |
EC number |
1.1.99.2: With other acceptors |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A7MBI3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A7MBI3-F1 | Predicted | AlphaFoldDB |
77 variants for A7MBI3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs483282600 | 7 | Y>S | No | EVA | |
| rs464836502 | 8 | L>R | No | EVA | |
| rs478433452 | 9 | G>A | No | EVA | |
| rs460004433 | 11 | V>G | No | EVA | |
| rs441649695 | 13 | G>* | No | EVA | |
| rs443096256 | 49 | F>V | No | EVA | |
| rs476154854 | 50 | D>G | No | EVA | |
| rs431976744 | 52 | V>G | No | EVA | |
| rs464998066 | 53 | I>L | No | EVA | |
| rs434499833 | 58 | I>N | No | EVA | |
| rs482128607 | 72 | P>L | No | EVA | |
| rs470106141 | 73 | A>S | No | EVA | |
| rs458804358 | 76 | I>F | No | EVA | |
| rs440446552 | 79 | L>Q | No | EVA | |
| rs476073158 | 80 | E>D | No | EVA | |
| rs461336267 | 80 | E>K | No | EVA | |
| rs443023710 | 80 | E>V | No | EVA | |
| rs457663978 | 81 | K>E | No | EVA | |
| rs475137231 | 137 | L>F | No | EVA | |
| rs456636929 | 137 | L>P | No | EVA | |
| rs444643477 | 142 | E>G | No | EVA | |
| rs452667180 | 143 | Q>K | No | EVA | |
| rs434281074 | 143 | Q>R | No | EVA | |
| rs469110742 | 162 | Q>* | No | EVA | |
| rs477179654 | 169 | Q>P | No | EVA | |
| rs465199646 | 170 | E>G | No | EVA | |
| rs479759200 | 171 | D>E | No | EVA | |
| rs446756950 | 171 | D>Y | No | EVA | |
| rs460456284 | 178 | Y>* | No | EVA | |
| rs442018360 | 179 | C>Y | No | EVA | |
| rs481543657 | 180 | R>K | No | EVA | |
| rs464028243 | 183 | M>I | No | EVA | |
| rs437535383 | 183 | M>K | No | EVA | |
| rs449564052 | 183 | M>L | No | EVA | |
| rs449564052 | 183 | M>V | No | EVA | |
| rs445698798 | 184 | A>T | No | EVA | |
| rs466683369 | 186 | D>V | No | EVA | |
| rs478803679 | 186 | D>Y | No | EVA | |
| rs448275101 | 187 | C>F | No | EVA | |
| rs481339352 | 187 | C>W | No | EVA | |
| rs444371957 | 188 | P>L | No | EVA | |
| rs462871093 | 188 | P>S | No | EVA | |
| rs483001197 | 189 | Y>D | No | EVA | |
| rs458171803 | 190 | T>I | No | EVA | |
| rs439727176 | 191 | G>R | No | EVA | |
| rs454213194 | 193 | V>G | No | EVA | |
| rs137666231 | 198 | V>G | No | EVA | |
| rs448673964 | 199 | A>D | No | EVA | |
| rs448673964 | 199 | A>G | No | EVA | |
| rs438303174 | 201 | S>L | No | EVA | |
| rs451996488 | 203 | A>S | No | EVA | |
| rs433628057 | 203 | A>V | No | EVA | |
| rs448156354 | 205 | D>G | No | EVA | |
| rs469206121 | 207 | Q>P | No | EVA | |
| rs450810570 | 208 | E>Q | No | EVA | |
| rs477344640 | 209 | A>P | No | EVA | |
| rs458083940 | 209 | A>V | No | EVA | |
| rs460633589 | 214 | L>F | No | EVA | |
| rs1116063313 | 216 | N>D | No | EVA | |
| rs442127097 | 218 | E>* | No | EVA | |
| rs475001916 | 218 | E>G | No | EVA | |
| rs475001916 | 218 | E>V | No | EVA | |
| rs456621950 | 224 | M>L | No | EVA | |
| rs720461803 | 231 | R>K | No | EVA | |
| rs471604520 | 236 | M>R | No | EVA | |
| rs432089339 | 236 | M>V | No | EVA | |
| rs453037748 | 237 | K>N | No | EVA | |
| rs434641688 | 238 | Y>N | No | EVA | |
| rs467661418 | 239 | P>S | No | EVA | |
| rs378609715 | 322 | N>S | No | EVA | |
| rs442023816 | 365 | F>L | No | EVA | |
| rs471959841 | 404 | V>A | No | EVA | |
| rs453592934 | 414 | N>H | No | EVA | |
| rs435222011 | 424 | G>C | No | EVA | |
| rs449736323 | 443 | A>S | No | EVA | |
| rs437782285 | 448 | A>T | No | EVA | |
| rs464370592 | 449 | I>L | No | EVA |
No associated diseases with A7MBI3
4 regional properties for A7MBI3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Helix-hairpin-helix DNA-binding motif, class 1 | 71 - 90 | IPR003583-1 |
| domain | Helix-hairpin-helix DNA-binding motif, class 1 | 106 - 125 | IPR003583-2 |
| domain | Holliday junction DNA helicase RuvA, C-terminal | 158 - 200 | IPR011114 |
| domain | DNA helicase, Holliday junction RuvA type, domain I, bacterial | 1 - 60 | IPR013849 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.1.99.2 | With other acceptors |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| (S)-2-hydroxy-acid oxidase activity | Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide. |
| 2-hydroxyglutarate dehydrogenase activity | Catalysis of the reaction: (S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| small molecule metabolic process | The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVPALRYLGS | VCGRARGIFP | GGFSAAHTPA | SGKSRLLCQG | GRRASTSSFD | IVIIGGGIVG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LASARALILR | HPALSIGVLE | KEKNLAVHQT | GHNSGVIHSG | IYYKPESLKA | KLCVQGAALI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YEYCNQKGIS | YKQCGKLIVA | VEQEEIPRLQ | ALYERGLQNG | VQGLRLIQQE | DIKKKEPYCR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GLMAIDCPYT | GIVDYRQVAF | SFAKDFQEAG | GSVLTNFEVE | DIEMARESPS | RSKDGMKYPI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VIRNTKGEEV | RCQYVVTCAG | LYSDRISELS | GCNPNPRIVP | FRGDYLVLKP | EKRYLVKGNI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YPVPDSRFPF | LGVHFTPRMD | GNIWLGPNAI | LAFKREGYRP | FDFSARDIMD | IIIKSGLIKL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VFQNFSYGVN | EMYKACFLSA | TVKHLQKFIP | EITISDVLRG | PAGVRAQALD | RDGNLIEDFV |
| 430 | 440 | 450 | 460 | ||
| FDGGVGDIGN | RILHVRNAPS | PAATSSLAIS | GMIADEVQQR | FKL |