A7KAK6

PR
Gene name
ATG26
Protein name
Sterol 3-beta-glucosyltransferase
Names
Autophagy-related protein 26
Species
Pichia angusta (Yeast) (Hansenula polymorpha)
KEGG Pathway
EC number
2.4.1.173: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

430-516 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A7KAK6

Entry ID Method Resolution Chain Position Source
AF-A7KAK6-F1 Predicted AlphaFoldDB

No variants for A7KAK6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A7KAK6

No associated diseases with A7KAK6

3 regional properties for A7KAK6

Type Name Position InterPro Accession
domain Asparagine synthase 235 - 542 IPR001962
domain Glutamine amidotransferase type 2 domain 2 - 191 IPR017932
domain Asparagine synthase, N-terminal domain 2 - 207 IPR033738

Functions

Description
EC Number 2.4.1.173 Hexosyltransferases
Subcellular Localization
  • Cytoplasm
  • Preautophagosomal structure membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
phagophore assembly site membrane A cellular membrane associated with the phagophore assembly site.

4 GO annotations of molecular function

Name Definition
brassicasterol glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + brassicasterol <=> UDP(3-) + 3-O-beta-D-glucosyl-brassicasterol + H+.
cholesterol alpha-glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + cholesterol = UDP + cholesteryl beta-D-glucoside + H+.
soladodine glucosyltransferase activity Catalysis of the reaction: UDP-alpha-D-glucose + solasodine <=> UDP + solasodine 3-O-beta-D-glucopyranoside + H+.
sterol 3-beta-glucosyltransferase activity Catalysis of the reaction: UDP-glucose + a sterol = UDP + an O-glucosylsterol.

5 GO annotations of biological process

Name Definition
autophagy The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
lipid glycosylation Covalent attachment of a glycosyl residue to a lipid molecule.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
sterol biosynthetic process The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSGIESTEEP CDSMTESQSL SPLEPEERQT RKDSGLQSQS LTKRHFAFSP HRLITSISRH
70 80 90 100 110 120
TSPHKPRPKS ESRVPVPKLH SLPPQRLASP ERDKPSIEGI SKSFVSFLTA ASVYAGFQDL
130 140 150 160 170 180
EGEDQQVSPD DVSAGESEDQ QADESSDEQE DDDQDDRTFY ATDPSPTELT INENTPLPEP
190 200 210 220 230 240
EPPRRTLRKA RSRFEFSVVK RLSENENDQL AQKRAIALSN KLKRTFDISD TDVFISDYPC
250 260 270 280 290 300
WLMGDVLLQG HLYITKHHIL FFAFLPKKQG SISKSGALTT KSYPSLREHR KWAVLRNNTF
310 320 330 340 350 360
SVYSNSTDLY FPLLVIDLRT ALRAEILQSS STKQNPSKPV WIRIITESRT HWFLADNLAS
370 380 390 400 410 420
ARSWVSSLKK HIFASRNKGD QVAIKIPLQN VVDLELTSVI GVTKNLRIKV IESADTFAID
430 440 450 460 470 480
DYFLMFFSRG EKAVEDIKKV IHDAGMEISE GTSTESEDEQ GVDNNLLKSK IELLKKSPSM
490 500 510 520 530 540
VQTSSKSNVP VIRMDEPADD FSQEQESAES SKPVSDDEIV SADDNQELEE KQPQDNLANA
550 560 570 580 590 600
EKENHDKVSR ANSRRTWSTR SLVQGLTAIT QGWMSPSPMA HFDEKYAVLR GEEDSYFVKD
610 620 630 640 650 660
AEQRKAATER FRKHFSLTDG EKLIATYHAY LVKGIPAYGK IYLGSNEMCF RSTLPGTGTI
670 680 690 700 710 720
MILPFSDIEN VNKEKGFRFG YSGLVVVIHG HEELFFEFAS DQARDDCEFM LLKQMDMFKK
730 740 750 760 770 780
GSTDSSPPNA SEGSSDESCN LAESNTSLAS ARLRMFENRI HDAIGLDVPI IIEEHPLTKT
790 800 810 820 830 840
KVRPLKSYRF TLLTIGSRGD VQPYIALGKA LMKEGHQVRI VTHAEFEPWI KKHGIRFASI
850 860 870 880 890 900
AGDPSELMAL MVTHPTINYN FIKEAKSKFR SWIDDLLVTS WKACQDTDIL IESPSSICGI
910 920 930 940 950 960
HIAEKLQIPY FRAFTMPWTR TRAYPHAFMV PDQKLGGAYN YMTHVAFENG YWRGTAHQVN
970 980 990 1000 1010 1020
KWRVETLGLP KTSLAEMKQN NVPFLYNVSP TVFPPSVDFA EWVKVTGYWF LDESETYQPP
1030 1040 1050 1060 1070 1080
EVLTKFIEQA RKDGKKVVYI GFGSIVVSKP SELTQAVVDA VLEADVRCIL NKGWSDRLGT
1090 1100 1110 1120 1130 1140
KTEIEVVLPP EIYNAGSVPH DWLFPQIDAA VHHGGSGTTG ASLRFGVPTI IKPFFGDQKF
1150 1160 1170 1180 1190 1200
YAGRVEDLGC GVSLKDLNYK SLARALKEVT TNTRIIEKAK LVGARIRSET GVQTAIETIY
1210 1220 1230 1240
NEMEYARSLS ISKVKQVSVV KSDEEFDDDK DEEVEGSWLL V