A7IMR0

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
KEGG Pathway
xau:Xaut_4081
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

31-101 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A7IMR0

Entry ID Method Resolution Chain Position Source
AF-A7IMR0-F1 Predicted AlphaFoldDB

No variants for A7IMR0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A7IMR0

No associated diseases with A7IMR0

4 regional properties for A7IMR0

Type Name Position InterPro Accession
domain DHHA1 domain 742 - 881 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 654 - 704 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 6 - 556 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 2 - 717 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSGVNEIRSS FIDYFVKEGH EAVASSPLVP QNDPTLMFTN AGMVQFKNVF TGVEKRPYSR
70 80 90 100 110 120
AATSQKCVRA GGKHNDLDNV GYTARHHTFF EMLGNFSFGD YFKDRAIELA WNLVTRTFEL
130 140 150 160 170 180
PRDRLVVTVF SEDEEAYGLW KKIAGLSDDK IIRIPTSDNF WSMGDTGPCG PCSEIFFDHG
190 200 210 220 230 240
PNVPGGPPGS PDQDGDRFIE IWNLVFMQFE QLPGGERLAL PRPSIDTGMG LERVSAVLQG
250 260 270 280 290 300
VHDNYDTDLM RALIAEVAEL TSVNPDGPQK ASHRVIADHL RASVFLTADG VLPSNEGRGY
310 320 330 340 350 360
VLRRIMRRAM RHAQLLGAKD PLMHRLVPVL VREMGRAYPE IVRAESLAEE TLLLEETRFR
370 380 390 400 410 420
RTLERGLSIL EEESTGLTSG GQFPGEVAFK LYDTYGFPLD LTQDALRARG ISVDTTAFDA
430 440 450 460 470 480
AMARQKAEAR ASWAGSGEAA TDTLWFSVRD EVGATEFLGY ETEKAEGVVA ALVRDGAVVD
490 500 510 520 530 540
SLAAGEKGLV ILNQTPFYAE SGGQVGDIGR VSGEGGVAAQ VVATQKKLGD LFVHEVKVET
550 560 570 580 590 600
GTLKRGTALV LEVDHARRAA VRANHSATHL LHEALRRVLG DHVAQKGSLV APDRLRFDFS
610 620 630 640 650 660
HPKPLSGGEL AEVETIANRF VLRNEPVETR IMAVDDAITS GARALFGEKY GDEVRVVSMG
670 680 690 700 710 720
TDDGNGAPYS VELCGGTHVK RTGDIGLISV LSESAVASGV RRIEALTADA ARRHLNAASA
730 740 750 760 770 780
ALAGTAAVLK APVAEVEARV ATLVEERRRL ERELAEARKK LAMGGGGEAS GDAVRTVGDI
790 800 810 820 830 840
KLLARRVEGI EIKDLKGLVD EGKKQIGSGV VAIVGVTSDG KAGIVVGVTA DLIARFDAVA
850 860 870 880
LVRVGSEALG GKGGGGRPDM AQAGGPDGAK AEAALDAIAA AMAG