A7I338

PR
Gene name
gltX2
Protein name
Glutamate--tRNA ligase 2
Names
Glutamyl-tRNA synthetase 2, GluRS 2
Species
Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A)
KEGG Pathway
cha:CHAB381_1380
EC number
6.1.1.17: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

72-142 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A7I338

Entry ID Method Resolution Chain Position Source
AF-A7I338-F1 Predicted AlphaFoldDB

No variants for A7I338

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A7I338

No associated diseases with A7I338

3 regional properties for A7I338

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 6 - 17 IPR001412
domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain 3 - 301 IPR020058
domain Aminoacyl-tRNA synthetase, class I, anticodon-binding 324 - 423 IPR045462

Functions

Description
EC Number 6.1.1.17 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glutamate-tRNA ligase activity Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
glutamyl-tRNA aminoacylation The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. The glutamyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamic acid-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MYRFAPSPTG DMHIGNLRAA IFNYICSLQD KSGFILRIED TDTARNISGK GEEIKEILKQ
70 80 90 100 110 120
FGIKWDKLYI QSENLKFHRE LASKLLNDKK AFCCFCSEEE LAAKKAAAKK AGVAYRYDGT
130 140 150 160 170 180
CEKLSDLEVL NCEKPFVIRM KKPNRILKFN DLIKGEIGFE PENIDSFVIM RVDKTPTYNF
190 200 210 220 230 240
ACAVDDMLEG VTCVIRGEDH VSNTPKQNWI RECLGYTEEI SYAHLPIILN EDGKKMSKRE
250 260 270 280 290 300
NSSSVKWLLQ SGYLPEAIAN YLILLGNKTP CEVFTLDEAV EWFDISKISK NPAKFDISKL
310 320 330 340 350 360
AFLNREHIKR ADSARLVEVF GLDESFSELI KFYTQEASLV GEIKEKIKSI FSKKEIPAEF
370 380 390 400 410 420
AENVKILKDE ILKIKELPEN FENFKEILTK ATNLKGKNFF MPLRILLTGA NHGPELKELY
430
PLLRSQIKRI VNL