A7I328

PR
Gene name
purA
Protein name
Adenylosuccinate synthetase
Names
AMPSase, AdSS, IMP--aspartate ligase
Species
Campylobacter hominis (strain ATCC BAA-381 / LMG 19568 / NCTC 13146 / CH001A)
KEGG Pathway
cha:CHAB381_1370
EC number
6.3.4.4: Other carbon--nitrogen ligases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

81-151 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A7I328

Entry ID Method Resolution Chain Position Source
AF-A7I328-F1 Predicted AlphaFoldDB

No variants for A7I328

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A7I328

No associated diseases with A7I328

2 regional properties for A7I328

Type Name Position InterPro Accession
binding_site Adenylosuccinate synthase, GTP-binding site 11 - 18 IPR018220
active_site Adenylosuccinate synthase, active site 129 - 140 IPR033128

Functions

Description
EC Number 6.3.4.4 Other carbon--nitrogen ligases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
adenylosuccinate synthase activity Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate.
GTP binding Binding to GTP, guanosine triphosphate.
magnesium ion binding Binding to a magnesium (Mg) ion.

1 GO annotations of biological process

Name Definition
'de novo' AMP biosynthetic process The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSKADLIIGS QWGDEGKGKI VDMLCANYDY VCRSGGGHNA GHTIWVDGVR YAMHLVPSGI
70 80 90 100 110 120
LHENIINIIG NGVVVNPDVL IAEMAQFKNL KGRFFISEKA HLNLEHHSLI DQAKERAKGD
130 140 150 160 170 180
KAIGTTGKGI GPAYADKVNR TGHRVGELLN PEKLCENLMK EFDENAKFYD ALNIKIPEKI
190 200 210 220 230 240
AVFNELKRFK EFLAPYIANT TEMLWKALDE NKKVLVEGAQ GSLLDIDHGT YPYVTSSNTV
250 260 270 280 290 300
ASGACTGLGL APKDIGEVIG IVKAYTTRVG NGAFPSEAND EWGEKMCQIG KEFGTTTGRK
310 320 330 340 350 360
RRCGWFDAVC VKYSARLSGI DKFALMKLDV LDGFEKVKIC TAYKLNGEII DYFPCNLESV
370 380 390 400 410
EPVYEEMDGW DSIKGVKKFS DLPENAQKYI KRIEELTNMR AGFISTSPER DDTIIL