A7HM24

PR
Gene name
rpoA
Protein name
DNA-directed RNA polymerase subunit alpha
Names
RNAP subunit alpha, RNA polymerase subunit alpha, Transcriptase subunit alpha
Species
Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
KEGG Pathway
fno:Fnod_1110
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

214-283 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A7HM24

Entry ID Method Resolution Chain Position Source
AF-A7HM24-F1 Predicted AlphaFoldDB

No variants for A7HM24

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A7HM24

No associated diseases with A7HM24

3 regional properties for A7HM24

Type Name Position InterPro Accession
domain RNA polymerase, alpha subunit, C-terminal 258 - 316 IPR011260
domain DNA-directed RNA polymerase, insert domain 66 - 157 IPR011262
domain DNA-directed RNA polymerase, RpoA/D/Rpb3-type 22 - 232 IPR011263

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIQITGRKFK LEEQVEHEDH YYARYSLSPL EKGYAVTVGN TLRRVLLSSI PSFAITDVRF
70 80 90 100 110 120
VKPEKYHEFD TIEGAKEDIM DILLNLKKVQ LRVDTYVESP VKLTINKKGP GVLTAGDIEC
130 140 150 160 170 180
PAGVVVVNPG HYLATLNEDA DLEIELYATF GKGFVPAADR NERPEIGWIV LDGVYSPVIK
190 200 210 220 230 240
VNWLVENVRV DKRTDYEKLI LEIWTKKSIK PSEALKHSLK IILDHFMFIE QSLSDVEELP
250 260 270 280 290 300
IPIIQETAVV TEEIGSPEDV MSKKVEELEL SARSLNCLKR DKIETIGDLL SRTEEELMKI
310 320
KNFGLKSLEE VREKLRDKFG LSLRKGDK