A7HJX5

PR
Gene name
valS
Protein name
Valine--tRNA ligase
Names
Valyl-tRNA synthetase, ValRS
Species
Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
KEGG Pathway
fno:Fnod_0343
EC number
6.1.1.9: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

782-867 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A7HJX5

Entry ID Method Resolution Chain Position Source
AF-A7HJX5-F1 Predicted AlphaFoldDB

No variants for A7HJX5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A7HJX5

No associated diseases with A7HJX5

5 regional properties for A7HJX5

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 42 - 53 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 15 - 561 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 603 - 746 IPR013155
domain Valyl-tRNA synthetase, tRNA-binding arm 799 - 863 IPR019499
domain Valyl tRNA synthetase, anticodon-binding domain 560 - 691 IPR033705

Functions

Description
EC Number 6.1.1.9 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
valine-tRNA ligase activity Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEIGTRYDPK NIEMKWYKHW LEKKYFTPRG AGPKYSIVIP PPNITGKIHM GHALNITIQD
70 80 90 100 110 120
ILSRYKRMKG FDVLWLPGED HAGIATQTAV ERYLSTQGKS RRDFSRDEFL NIVWNWANKY
130 140 150 160 170 180
RQEIKNQIMS IGASVDWTRE RFTLDEGLSK AVRKVFVDMY KKGLIYKGKY IVNWCHRCGT
190 200 210 220 230 240
VLSDEEVDYH EEEGALYHIK YPIKGEDDYI IIATTRPETM LGDTAVAVHP SDERYRKYVG
250 260 270 280 290 300
KIAILPLVGR EIPVIADNYV DPSFGTGALK VTPAHDTNDY LIGQRHNLPF VDIFDENIVI
310 320 330 340 350 360
NENGGKFKGM TAEQARKAVV EELEAQGYLV KIEKMKHSVG RCYRCDTVVE PRLMDQWFVS
370 380 390 400 410 420
MKPLAKRAIE AVENGEVTFI PDRWKKVYLN WMYEIRDWCI SRQLWWGHRI PVWQCQDCGH
430 440 450 460 470 480
YNVSENEPVK CEKCGSTNLK QDEDVLDTWF SSALWPFSTM GWPEKTPDLE RYYPTDVLVT
490 500 510 520 530 540
GFDIIFFWVA RMIMMGYEFM DEKPFKEVYI HQLVRDKYGR KMSKSLGNGI DPLEVIDEYG
550 560 570 580 590 600
ADPMRFTLAI LAAQGRDLKL DVRFFDTYKK FANKIWNATR FVLMNLEDFE KVDIKLSKLK
610 620 630 640 650 660
LSDKWILSRL QKTIQKISEA LDSYDFNIAA NEIYNFFWDE LCDWYIEAVK NRLKTEERKV
670 680 690 700 710 720
VQNVLVYVLD MSLRLLHPFM PFLTEELWTK LPTSGESIVV AQWPEIEENF IDENSEKRFM
730 740 750 760 770 780
QLMNIIRGIR NIRAEVNVPQ STKVKTFVKG TLTDEEQEYI KFLGNVESIE FVEKRPELSA
790 800 810 820 830 840
TAYISLENEV YVSLGTLIDV KSEVERLRKK VEKLKSDMEK FAKKLEDENF LKNAPEDIVE
850 860
ETKEKQRLFQ EQIARIEQII SDLEAKA