A7HH87

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Anaeromyxobacter sp (strain Fw109-5)
KEGG Pathway
afw:Anae109_3904
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

359-500 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A7HH87

Entry ID Method Resolution Chain Position Source
AF-A7HH87-F1 Predicted AlphaFoldDB

No variants for A7HH87

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A7HH87

No associated diseases with A7HH87

4 regional properties for A7HH87

Type Name Position InterPro Accession
domain DHHA1 domain 762 - 898 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 683 - 725 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 6 - 585 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 2 - 738 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKTAAQIREL FLRFFEEKAH RRVPSSSLVP QNDPTLLFTN AGMNQFKDVF TGREKRDYSR
70 80 90 100 110 120
ATTAQKCVRA GGKHNDLENV GFTARHHTFF EMLGNFSFGD YFKKEAIAWA WELVTSERWL
130 140 150 160 170 180
AISKERLAAT VFAGEGTLPW DEEAYRLWEA QGVPPERIHK LGAKDNFWAM GDTGPCGPCS
190 200 210 220 230 240
ELHFFQGNDI PCAEEKAGRT CQGVACDCDR WLEIWNLVFM QFERGADGGL TPLPKPSIDT
250 260 270 280 290 300
GAGLERMAAV VQGKRSNYDI DAFQSIIRAI EKLAGKRYGA TDADDDVSMR VIADHARATT
310 320 330 340 350 360
FLVGDGVLPA NEGRGYVLRR IMRRAIRHGK RLGLERPFLA DVCEAVMEEM GGAYPETREN
370 380 390 400 410 420
RAFIVKVAGQ EEESFRRTLD KGLAILETEM RKAIPPETHL GKPATPPPSA PRPVIDGKLA
430 440 450 460 470 480
FQLYDTFGFP LDLTRVIAAE RGFDVDEQGF DRNMAEQRAR SEWKGSGEQA VGDLHKQIAS
490 500 510 520 530 540
ELGETRFLGY EAPTARAEVK ALLANGARAA KAARGDKVEV VTAATPFYGE SGGQVGDQGS
550 560 570 580 590 600
IAAPGGRVRV EDTRRPVPGL VTHVGVVEEG ELAVGDLVEL AVDDRRRDLI RANHSATHLL
610 620 630 640 650 660
QLALRETLGD HVKQAGSIVA PDYLRFDFSH FQPLSEEELN AIERRVNELV RENAETETAV
670 680 690 700 710 720
LKLEDARQSG AMMIFGEKYG DVVRVVRLGP SKELCGGTHV RRTGDIAFFK IGSEESIAAG
730 740 750 760 770 780
VRRIVAYTGP QAIELSQREA DELRRAAALF KAGAFEVAQK IEQTQKRVKD LERALDEAKG
790 800 810 820 830 840
KIASAQSGDL AAQARDVKGA KVLAVRVQGD GKSLRELADK LRDRLGTGVV ALGAEQDGKA
850 860 870 880 890 900
ILLVAVTKDL TARLKAGELV KEAAKLVGGS GGGKPDLAQA GGSDPAGLEK ALAKVQELAV
AALG