A7H3U4

PR
Gene name
ligA
Protein name
DNA ligase
Names
Polydeoxyribonucleotide synthase [NAD(+)]
Species
Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97)
KEGG Pathway
cjd:JJD26997_1083
EC number
6.5.1.2: Forming phosphoric ester bonds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

9-89 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A7H3U4

Entry ID Method Resolution Chain Position Source
AF-A7H3U4-F1 Predicted AlphaFoldDB

No variants for A7H3U4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A7H3U4

No associated diseases with A7H3U4

7 regional properties for A7H3U4

Type Name Position InterPro Accession
domain BRCT domain 570 - 647 IPR001357
domain NAD-dependent DNA ligase, OB-fold 308 - 384 IPR004150
domain NAD-dependent DNA ligase, adenylation 4 - 304 IPR013839
domain NAD-dependent DNA ligase, N-terminal 1 - 432 IPR013840
active_site NAD-dependent DNA ligase, active site 107 - 136 IPR018239
conserved_site NAD-dependent DNA ligase, conserved site 318 - 333 IPR033136
domain DisA/LigA, helix-hairpin-helix motif 494 - 551 IPR041663

Functions

Description
EC Number 6.5.1.2 Forming phosphoric ester bonds
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
DNA ligase (NAD+) activity Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m).
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKKEEYLEKV ALANLWMRAY YEKDEPLASD EEYDALIREL RVFEEQNKDE VSKDSPTQKI
70 80 90 100 110 120
APTIQSEFKK IAHLKRMWSM EDVFDESELR AWAKRAKCEK NFFIEPKFDG ASLNLLYENG
130 140 150 160 170 180
KLVSGATRGD GEVGEDITLN VFEIENIPKN IAYKKRIEIR GEVVILKDDF EKINEKRALL
190 200 210 220 230 240
NQSLFANPRN AASGSLRQLD TSITKERNLK FYPWGVGENT LNFTKHSEVM QFVRDLGFLK
250 260 270 280 290 300
DDFIKLCANL DEVLKAYDEL LTLREKKPMM MDGMVVRVDD LALCEELGYT VKFPKFMAAF
310 320 330 340 350 360
KFPALEKTTR LIGINLQVGR SGVITPVAVL EPVNLDGVVV KSATLHNFDE IARLDVKIND
370 380 390 400 410 420
FVSVIRSGDV IPKITKVFKE RREGLEMEIS HPKLCPTCQS ELLDEGTLIK CQNIDCEDRL
430 440 450 460 470 480
VNSIIHFVSK KCLNIDGLGE NIVELLYKHK KITTLESIFH LKFSDFEGLE GFKEKKINNL
490 500 510 520 530 540
LNAIEQAREC ELFRFITALG IEHIGEVAAK KLSLSFGKEW HKQSFEAYVN LEGFGEQMAL
550 560 570 580 590 600
SLCEFTRVNH TRIDEFYKLL NLKIEKLEVK SDSVIFGKTF VITGTLSRPR DEFKALIENL
610 620 630 640
GGKVSGSVSK KTDYVLFGEE AGSKLSKAKE LEVKCIDESA FNELVKE