A7GZI1

PR
Gene name
ispDF
Protein name
Bifunctional enzyme IspD/IspF
Names
Species
Campylobacter curvus (strain 52592)
KEGG Pathway
ccv:CCV52592_0202
EC number
2.7.7.60: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

119-195 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A7GZI1

Entry ID Method Resolution Chain Position Source
AF-A7GZI1-F1 Predicted AlphaFoldDB

No variants for A7GZI1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A7GZI1

No associated diseases with A7GZI1

2 regional properties for A7GZI1

Type Name Position InterPro Accession
domain 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 199 - 366 IPR003526
conserved_site 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, conserved site 245 - 260 IPR020555

Functions

Description
EC Number 2.7.7.60 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP.
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + CTP = 4-CDP-2-C-methyl-D-erythritol + diphosphate.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate.
terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLDISLIMLG AGNSSRFELP VKKQWLRIGS DPLWLAATKN LSEFYTFKDI IVVSKECEYM
70 80 90 100 110 120
ARFAPHYKFV TGGDTRQQSL KNALNLVSSQ FVLVSDIARP CITHELFSKI IEGSKQANCV
130 140 150 160 170 180
VPALKIADTA YFGDEVIDRD KIKLIQTPQL SKTNLLKQAL ETDTLYTDDS SAMRAVGASV
190 200 210 220 230 240
WHVLGDERAH KITTKSDLAK IPCLIPPSNE HFTGIGFDAH EFERGRELWL CGEKIEYEFG
250 260 270 280 290 300
LKAHSDGDVA LHALTDAILG AAGLGDIGEL FPDTDAEFKG ISSLLLLQEA YKKVQSVGFE
310 320 330 340 350 360
LVNADITIMA ERPKISKFKR KMEANIAGAL NLAPNRINVK ATTTEKLGFV GRGEGIAVIA
370
SANLKYYDWT K