A7GZA4

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Campylobacter curvus (strain 52592)
KEGG Pathway
ccv:CCV52592_0686
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

24-102 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A7GZA4

Entry ID Method Resolution Chain Position Source
AF-A7GZA4-F1 Predicted AlphaFoldDB

No variants for A7GZA4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A7GZA4

No associated diseases with A7GZA4

4 regional properties for A7GZA4

Type Name Position InterPro Accession
domain DHHA1 domain 720 - 843 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 643 - 686 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 5 - 545 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 1 - 699 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQNLDVREAY LNFFKSKGHE ITPSAPLVPN DATLLFTNAG MVPFKSIFTG EVPRPTPPIR
70 80 90 100 110 120
TSCQTCIRAG GKHNDLDNVG YTARHHTFFE MLGNFSFGEY FKKDAIAYAW EFVTQVLKLP
130 140 150 160 170 180
VDRLYVTVHE SDDEAFELWA RHIARDRIYR FGDHDNFWQM GDTGPCGPCS EIFYDQGGEH
190 200 210 220 230 240
FNTPEDYMGG DGDRFLEIWN LVFMQYERSA DGKLSPLPKP SIDTGMGLER VTAIMEGKFS
250 260 270 280 290 300
NYDSSLFMPL IDEVAKLCGK PYSYDSGASY RVISDHIRSV TFLLAQGTTF DKEGRGYVLR
310 320 330 340 350 360
RILRRAIRHG YLLGIKEPFM YKLVDKVCEM MGGHYTYLNE KKAAVKEQVR LEEERFLATI
370 380 390 400 410 420
ASGLELFNEE LAKTKEIFSG ETAFKLYDTY GFPLDLTADM LREKGLKVDE AKFDELMSEQ
430 440 450 460 470 480
KARAKAAWKG SGDKSSKGDF KQLLEEFGEN KFSGYDELER QSKILALLDN DFKRVQNLRA
490 500 510 520 530 540
GESGWVMFDV TPFYAQSGGQ TGDTGEITGV GKVLDTQKFH GLNLSQVEVG KQIKTGDVLN
550 560 570 580 590 600
LKVSDARAEI ARHHSATHLL HAALRKILGT HVAQAGSNVE ADRLRFDFSH PKALTSEELE
610 620 630 640 650 660
MIEKFVNDAV ASSAAAKTEI MDIEAAKNSG AIALFGEKYA ENVRVLSLGN VSKELCGGTH
670 680 690 700 710 720
VKNVSEIGAF FITKESGVSA GVRRIEAVCS RAALNLARGF RSELAEISNE LKTNEPMVAI
730 740 750 760 770 780
KKLKGEVREL KDKLKNIGDS HAIAFTSIND TKMGVAVVKS GDIKTMIDNY KNEFASLAIL
790 800 810 820 830 840
LLQVNDDKIA IAAGVKNAPI KAGEWVKMAA KILDGNGGGR DDFATAGGKN VPMIETAVKE
850
AFEFAKEKLL NA