A7GHV1

PR
Gene name
pbpA (CLI_3142)
Protein name
Penicillin-binding protein 1A
Names
PBP1a
Species
Clostridium botulinum (strain Langeland / NCTC 10281 / Type F)
KEGG Pathway
cbf:CLI_3142
EC number
2.4.1.129: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

94-187 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A7GHV1

Entry ID Method Resolution Chain Position Source
AF-A7GHV1-F1 Predicted AlphaFoldDB

No variants for A7GHV1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A7GHV1

No associated diseases with A7GHV1

2 regional properties for A7GHV1

Type Name Position InterPro Accession
domain Glycosyl transferase, family 51 67 - 248 IPR001264
domain Penicillin-binding protein, transpeptidase 358 - 620 IPR001460

Functions

Description
EC Number 2.4.1.129 Hexosyltransferases
Subcellular Localization
  • Cell membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
penicillin binding Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system.
peptidoglycan glycosyltransferase activity Catalysis of the reaction: [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphosphoundecaprenol + GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.
serine-type D-Ala-D-Ala carboxypeptidase activity Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine.

5 GO annotations of biological process

Name Definition
cell wall organization A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
regulation of cell shape Any process that modulates the surface configuration of a cell.
response to antibiotic Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGKKKKKRKS SAFKIILNVF LSIFLVAGVA FGGIVFAMIK TAPPLNVQQV LTFDEPSILY
70 80 90 100 110 120
DDKGQYMDKV ITNEQRIVVD YKNVPQNLKN AFVSIEDERF YKHHGVDIKR FTGVILINVT
130 140 150 160 170 180
NKIKRSSKLQ GASTLTQQLI KNTVLSSEVS IKRKVQEMYL SIQLEKELSK DEILGAYMNS
190 200 210 220 230 240
IFLGGNALGV EAASKQYFNK SVKDLSLIEC AFIAGVPQSP SVYYPYSSAS KKNPSIYLNR
250 260 270 280 290 300
TKTVLYKMLD NGYITQNDYN KALKDLDSKK LAFAKPSAPS NKLAYEWFSI PAIEQVKKDL
310 320 330 340 350 360
KTQYKYDDKQ IHNLLVNGGL KIYTTMNKNL QDKTQNTIND AYYLNSYKSN GIIYPQASAV
370 380 390 400 410 420
IMDYHNGEVK TIVGGRGDQP ARSYNRAASY NYLRPAGSSI KPLTVYSAAI DSKKATAATG
430 440 450 460 470 480
FEDSPIPNNI GRKYSSGAPY NPRNTPDIYY GYVNVREALM RSINVVAVKL VDKIGLNTSI
490 500 510 520 530 540
QYAEKFGIPI DQHDRSSIAS LSLGELHKGT NPLIMAQAYG VFGNNGTYTE AKLYTKVVDR
550 560 570 580 590 600
TGKVLLEPKT NTKKVLSPEA AFITYDMLQG PVSESGTGPQ ANFGNMEVRG KTGTSSDMKN
610 620 630 640 650 660
LWFCGLTPYY SAAVWIGNDN SSTVDGVYSS TAARLWGDIM KEFHVNLPYK QVQKPASVVT
670 680 690 700 710 720
ANVDRISGKL PTQLSYRDPR GSTVYNEFFI NGTIPTEYDD IHVEAQINKL TGKLASKFTP
730 740 750 760 770 780
SFLVESRVFL RRDYSPGVEL LDQQWLLPYS IDEGGSLPPT EEKNNSNTRD KNKDKNKDKD
790 800 810 820
KNKNKDKNPS QDKPNNNNNN NNNDNNNNTK PPENDSNQNH EDNKNKQ