Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for A7FFU0

Entry ID Method Resolution Chain Position Source
AF-A7FFU0-F1 Predicted AlphaFoldDB

No variants for A7FFU0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A7FFU0

No associated diseases with A7FFU0

12 regional properties for A7FFU0

Type Name Position InterPro Accession
domain Protein kinase domain 620 - 883 IPR000719
domain Ephrin receptor ligand binding domain 21 - 203 IPR001090
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 621 - 879 IPR001245
conserved_site Tyrosine-protein kinase, receptor class V, conserved site 242 - 262 IPR001426
domain Sterile alpha motif domain 909 - 976 IPR001660
domain Fibronectin type III 324 - 532 IPR003961
active_site Tyrosine-protein kinase, active site 741 - 753 IPR008266
binding_site Protein kinase, ATP binding site 626 - 652 IPR017441
domain Tyrosine-protein kinase, catalytic domain 620 - 879 IPR020635
domain Ephrin receptor, transmembrane domain 544 - 617 IPR027936
domain Ephrin type-B receptor 1, ligand binding domain 22 - 197 IPR034231
domain EphB1, SAM domain 909 - 976 IPR042819

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Cell inner membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
small ribosomal subunit rRNA binding Binding to small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA.

1 GO annotations of biological process

Name Definition
ribosomal small subunit biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSEVEKTYCG FIAIVGRPNV GKSTLLNELL GQKISITSRK PQTTRHRIMG IHTEGPYQAI
70 80 90 100 110 120
YVDTPGLHIE EKRAINRLMN RAASSSLGDV ELVIFVVEGT HWTADDEMVV NKLRSLQCPV
130 140 150 160 170 180
LLAINKVDNV TDKTKLLPHM QFLSQQMNFL DVVPISAEKG MNVDTIASIV RKHMPEAEHH
190 200 210 220 230 240
FPEDYITDRS QRFMASEIIR EKLMRFLGEE LPYSVTVEIE QFVPNERGGY NIHGLILVER
250 260 270 280 290 300
EGQKKMVIGN KGSKIKVIGT EARQDMERMF EAKVHLELWV KVKSGWADDE RALRSLGYTD
DLK