A7FDD3
Gene name |
metE |
Protein name |
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase |
Names |
Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme |
Species |
Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) |
KEGG Pathway |
ypi:YpsIP31758_0264 |
EC number |
2.1.1.14: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A7FDD3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A7FDD3-F1 | Predicted | AlphaFoldDB |
No variants for A7FDD3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A7FDD3 | |||||
No associated diseases with A7FDD3
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.14 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity | Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate. |
| zinc ion binding | Binding to a zinc ion (Zn). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| methionine biosynthetic process | The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. |
| methylation | The process in which a methyl group is covalently attached to a molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTILNHTLGF | PRVGLKRELK | KAQESYWAGN | STQEELLNVG | RELRARHWQQ | QQQAGVDLVP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VGDFAWYDHV | LTTSLLLGNV | PERHQNADGS | IDIDTLFRIG | RGRAPTGKPA | AAAEMTKWFN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TNYHYMVPEF | QQGQQFKLGW | TQLLDEVDEA | LALGHKIKPV | LLGPITYLWL | GKVKGEQFDR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LSLLNDILPV | YQQVLAELAK | RGIEWVQIDE | PALVLELPQE | WLDAYQPAYQ | ALQGQVKLLL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TTYFDSIGHN | IDTIRALPVQ | GLHVDVVAGH | DDLAVLHKNL | PKEWLLSLGV | INGRNVWRAD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LSSWFERLQP | LVNSRPLWLG | SSCSLLHSPI | DLNEETRLDA | EVKSWFAFAL | QKCAELALLT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| QALNAPNDAK | LAELAAYSAP | IRARRSSSRV | HNAQVEQRLA | AITSQDIERQ | LPYEARAETQ |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RKRFNLPAWP | TTTIGSFPQT | TEIRGLRLDF | KQGRLDGKNY | RTGISEHIKQ | AIAEQERLGL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| DVLVHGEAER | NDMVEYFGEH | LDGFVFTQNG | WVQSYGSRCV | KPPVIIGDIS | RPEAITVEWA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KYAQSLTEKP | VKGMLTGPVT | ILCWSFPRED | VSRETIAKQI | ALALRDEVED | LEKAGIGIIQ |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IDEPALREGL | PLRRADWQAY | LQWAVDAFKL | NAAVAQNDTQ | IHTHMCYCEF | NDIMDSIAAL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| DADVITIETS | RSDMELLESF | EDFAYPNEIG | PGVYDIHSPN | VPSVEWIEAL | LRKAAQRIPA |
| 730 | 740 | 750 | |||
| ERLWVNPDCG | LKTRGWPETR | QALANMVLAA | QRLREEQI |