Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for A7ERA6

Entry ID Method Resolution Chain Position Source
AF-A7ERA6-F1 Predicted AlphaFoldDB

No variants for A7ERA6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A7ERA6

No associated diseases with A7ERA6

2 regional properties for A7ERA6

Type Name Position InterPro Accession
domain GB1/RHD3-type guanine nucleotide-binding (G) domain 76 - 315 IPR030386
domain Sey1/RHD3-like, three-helix bundle domain 391 - 830 IPR046758

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
  • Enriched in the cortical ER
  • Concentrated in punctae along the ER tubules
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.

1 GO annotations of biological process

Name Definition
endoplasmic reticulum membrane fusion The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDMATSNING HGDRPSPAAR FPTAPSVMTM NGNFASVGDA PTKEQYEHGI QVIDEQKEFN
70 80 90 100 110 120
PNLNEYLQYT DTAHSGFNYH LISVFGSQST GKSTLLNHLF GTQFGVMSER ERRQTTKGIW
130 140 150 160 170 180
MSKNKNQSSG ASESETMADN ILVMDVEGTD GRERGEDQDF ERKSALFALA TSEVLIVNIW
190 200 210 220 230 240
EHQVGLYQGA NMGLLKTVFE VNCQLFLKDK QSTPRSLLFF VIRDHLGTTP LANLKETLIQ
250 260 270 280 290 300
DLSAIWTSLS KPAGLENSKI EDYFDFAFAA LPHKILQPDK FITEVQKLGT RFRAGRKSAR
310 320 330 340 350 360
AEDAGFEGGV FLPEYHRRIP ADGFAVYTEG VWDQIVNNKD LDLPTQQELL AQFRCDEISR
370 380 390 400 410 420
EVLISFDAKI HPLEEKQGED VRSGKPTVIA DLGVTGKTAR TSTIKHFETQ ASRYHKAVYT
430 440 450 460 470 480
LKRTELEGKI DTRLKLLFHG QLLAAHKSGV ASFSDAVSTA VKNGQKRAAS YEFADIVERE
490 500 510 520 530 540
KEVALKTFEA EMKSLYIEEL SWTNFSSSYD LFEKDLNEVS GNLRKEEMRR LATHVERWVR
550 560 570 580 590 600
SRLNDSIGVE FNKLGSGRGG SGAPETGEKP ATEKDLWDRI WKTFTGTVKE AESKFIERAK
610 620 630 640 650 660
SFDASEDEIE IGLWRLRRKS WGVLRAKIDE EVMEGNILLK LRENFEDKFR YDEAGVPRIW
670 680 690 700 710 720
RPSDDIEGIY TKARESTLTL IPLLAKFKLL ETSSPPELPE WIGNTPASVD PKDEEDLTPI
730 740 750 760 770 780
GGVDEEEGKS LEEEMTVLSE AKRQDLVVRF KKTADGVYVE AKRSAIGGVA QVPLYFYGLL
790 800 810 820 830 840
LALGWNEIVA VLRNPIYFVF LILCGVAGYV TYTLNLWGPI IRMLNAASTQ GVEIGKEKLR
850 860 870 880
EFLKDSEVGR QALGMQGRDA GDSDAISLNT LDSRGKRVVR EDEDVDEI