A7A0P8

PR
Gene name
DRS1 (SCY_3572)
Protein name
ATP-dependent RNA helicase DRS1
Names
Deficiency of ribosomal subunits protein 1
Species
Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
KEGG Pathway
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-82 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A7A0P8

Entry ID Method Resolution Chain Position Source
AF-A7A0P8-F1 Predicted AlphaFoldDB

No variants for A7A0P8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A7A0P8

No associated diseases with A7A0P8

1 regional properties for A7A0P8

Type Name Position InterPro Accession
domain Heparinase II, N-terminal 150 - 314 IPR032518

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

4 GO annotations of biological process

Name Definition
cellular nitrogen compound metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells.
macromolecule metabolic process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
primary metabolic process The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
ribosome biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVVGTKKYSN LDFVPTISDS EDDVPILDSS DDEKVEAKKT TKKRKGKNNK KKVSEGDNLD
70 80 90 100 110 120
EDVHEDLDAG FKFDLDADDT TSNFQGWNFL AEGESNKDDA EAFVKKDVDL DKIIRRKGGL
130 140 150 160 170 180
VKMAHIDSKQ EEETEKEKVE KENDSDDEEL AMDGFGMGAP MNNGDENQSE EEEEEEEEEE
190 200 210 220 230 240
EEEEEEEEEQ EEMTLEKGGK DDEIDEEDDS EEAKADFYAP ETEGDEAKKQ MYENFNSLSL
250 260 270 280 290 300
SRPVLKGLAS LGYVKPSPIQ SATIPIALLG KDIIAGAVTG SGKTAAFMIP IIERLLYKPA
310 320 330 340 350 360
KIASTRVIVL LPTRELAIQV ADVGKQIARF VSGITFGLAV GGLNLRQQEQ MLKSRPDIVI
370 380 390 400 410 420
ATPGRFIDHI RNSASFNVDS VEILVMDEAD RMLEEGFQDE LNEIMGLLPS NRQNLLFSAT
430 440 450 460 470 480
MNSKIKSLVS LSLKKPVRIM IDPPKKAATK LTQEFVRIRK RDHLKPALLF NLIRKLDPTG
490 500 510 520 530 540
QKRIVVFVAR KETAHRLRII MGLLGMSVGE LHGSLTQEQR LDSVNKFKNL EVPVLICTDL
550 560 570 580 590 600
ASRGLDIPKI EVVINYDMPK SYEIYLHRVG RTARAGREGR SVTFVGESSQ DRSIVRAAIK
610 620 630 640 650 660
SVEENKSLTQ GKALGRNVDW VQIEETNKLV ESMNDTIEDI LVEEKEEKEI LRAEMQLRKG
670 680 690 700 710 720
ENMLKHKKEI QARPRRTWFQ SESDKKNSKV LGALSRNKKV TNSKKRKREE AKADGNGARS
730 740 750
YRKTKTDRIA DQERTFKKQK STNSNKKKGF KSRR