A7A061

PR
Gene name
SIR1 (SCY_3471)
Protein name
Regulatory protein SIR1
Names
Heterochromatin protein SIR1, Silent information regulator 1
Species
Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

301-372 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A7A061

Entry ID Method Resolution Chain Position Source
AF-A7A061-F1 Predicted AlphaFoldDB

No variants for A7A061

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A7A061

No associated diseases with A7A061

2 regional properties for A7A061

Type Name Position InterPro Accession
domain Sir1, ORC-binding domain 3 - 125 IPR021646-1
domain Sir1, ORC-binding domain 465 - 585 IPR021646-2

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Chromosome, centromere
  • Associated primarily with the HMR-E silencer at the HMR locus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromosome, centromeric region The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLQINSRLAV IDGWLVDTVK RKPINFRSPE VRLLLPNDDD YKKLSQQNLV DWTRLKKDSN
70 80 90 100 110 120
SVLVGVKSME LFKHIKLVLR EFFLLEDGRI ILKRIRSKLR YKVVKKLTCK CCRLNLPKWG
130 140 150 160 170 180
TVYIHPMLKD KEKPLAGVCE FSLDVNPDRE YPLIEINVSH QYIIIEGFLL YLNERRLYRW
190 200 210 220 230 240
NDNNLRSQVG LTKWAHLRKT YNPVSLDILY SLNSNFYFVK DDLLFQLLGK RVFVKFCKVM
250 260 270 280 290 300
ENGKCGKAPL WYRVKRTTTA KATHIAYAIS NSTAPDSFKS KNNDYRFIVR EKPIVENTIS
310 320 330 340 350 360
NLDYSDIKKQ QFTEAEVVKR KISADISQIE NVHTQFNSQK EKNNIRVNKV SSEVLDQISK
370 380 390 400 410 420
FPVSRVTLLL ISAGQDKNYI ELVEELARRL EKICIEKTTQ SLEEIRDTFQ ANPEMQARFD
430 440 450 460 470 480
KEYYQSIEEY KITLELIKED LLITLIKQME NMWAAEKKFS TEEEYVSPRF LVADGFLIDL
490 500 510 520 530 540
AEEKPINPKD PRLLTLLKDH QRAMIDQMNL VKWNDFKKYQ DPIPLKAKTL FKFCKQIKKK
550 560 570 580 590 600
FLRGADFKLH TLPTEANLKY EPERMTVSCS CVPILLDDQT VQYLYDDSII PEFEATSSYA
610 620 630 640 650
TKQSKCGGKM SLQMEPDLLF QEAIRRMRHL TAYDVLRRNY IAAFEELYMG NCND