A6ZU15

PR
Gene name
ROK1 (SCY_1898)
Protein name
ATP-dependent RNA helicase ROK1
Names
Rescuer of KEM1 protein 1
Species
Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
KEGG Pathway
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-139 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6ZU15

Entry ID Method Resolution Chain Position Source
AF-A6ZU15-F1 Predicted AlphaFoldDB

No variants for A6ZU15

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A6ZU15

No associated diseases with A6ZU15

6 regional properties for A6ZU15

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 278 - 286 IPR000629
domain Helicase, C-terminal 344 - 506 IPR001650
domain DEAD/DEAH box helicase domain 146 - 322 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 141 - 348 IPR014001
domain RNA helicase, DEAD-box type, Q motif 122 - 150 IPR014014
domain DDX52/Rok1, DEAD-box helicase domain 133 - 336 IPR044764

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

1 GO annotations of biological process

Name Definition
maturation of SSU-rRNA Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDIFRVLTRG ASVKKESGPK AKAADYSVIN GKDENHKEDN NESQIVKELD FFRNKRIISK
70 80 90 100 110 120
VEDDREKTTE NDSPNKEEKS GNDDGLIKPV ITNTVEASAL RKSYKGNVSG IDIPLPIGSF
130 140 150 160 170 180
EDLISRFSFD RRLLNNLIEN GFTEPTPIQC ECIPVALNNR DVLACGPTGS GKTLAFLIPL
190 200 210 220 230 240
VQQIIDDKQT AGLKGLIISP TKELANQIFI ECFKLSHKIF LEKKRPLQVA LLSKSLGAKL
250 260 270 280 290 300
KNKVVSDKKY DIIISTPLRL IDVVKNEALD LSKVKHLIFD EADKLFDKTF VEQSDDILSA
310 320 330 340 350 360
CREPSLRKAM FSATIPSNVE EIAQSIMMDP VRVIIGHKEA ANTNIEQKLI FCGNEEGKLI
370 380 390 400 410 420
AIRQLVQEGE FKPPIIIFLE SITRAKALYH ELMYDRINVD VIHAERTALQ RDRIIERFKT
430 440 450 460 470 480
GELWCLICTD VLARGIDFKG VNLVINYDVP GSSQAYVHRI GRTGRGGRSG KAITFYTKQD
490 500 510 520 530 540
SVAIKPIINV MKQSGCEVSE WMDKMAKMTR KEKESIKNGK AHKERKQITT VPKMDKAKRR
550 560
RQQEMIAASK RRKNEELSKK HFSK