A6ZSP9

PR
Gene name
LAG1 (SCY_2383)
Protein name
Sphingosine N-acyltransferase LAG1
Names
Longevity assurance factor 1, Longevity assurance protein 1
Species
Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
KEGG Pathway
EC number
2.3.1.24: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

3-88 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6ZSP9

Entry ID Method Resolution Chain Position Source
AF-A6ZSP9-F1 Predicted AlphaFoldDB

No variants for A6ZSP9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A6ZSP9

No associated diseases with A6ZSP9

2 regional properties for A6ZSP9

Type Name Position InterPro Accession
domain TRAM/LAG1/CLN8 homology domain 168 - 384 IPR006634
domain TRAM1-like protein 110 - 167 IPR013599

Functions

Description
EC Number 2.3.1.24 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
sphingosine N-acyltransferase activity Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine.

1 GO annotations of biological process

Name Definition
ceramide biosynthetic process The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTSATDKSID RLVVNAKTRR RNSSVGKIDL GDTVPGFAAM PESAASKNEA KKRMKALTGD
70 80 90 100 110 120
SKKDSDLLWK VWFSYREMNY RHSWLTPFFI LVCVYSAYFL SGNRTESNPL HMFVAISYQV
130 140 150 160 170 180
DGTDSYAKGI KDLSFVFFYM IFFTFLREFL MDVVIRPFTV YLNVTSEHRQ KRMLEQMYAI
190 200 210 220 230 240
FYCGVSGPFG LYIMYHSDLW LFKTKPMYRT YPDITNPFLF KIFYLGQAAF WAQQACVLVL
250 260 270 280 290 300
QLEKPRKDYK ELVFHHIVTL LLIWSSYVFH FTKMGLAIYI TMDVSDFFLS LSKTLNYLNS
310 320 330 340 350 360
VFTPFVFGLF VFFWIYLRHV VNIRILWSVL TEFRHEGNYV LNFATQQYKC WISLPIVFVL
370 380 390 400 410
IAALQLVNLY WLFLILRILY RLIWQGIQKD ERSDSDSDES AENEESKEKC E