A6ZPT1

PR
Gene name
AIM22 (SCY_2892)
Protein name
Putative lipoate-protein ligase A
Names
Altered inheritance rate of mitochondria protein 22
Species
Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
KEGG Pathway
EC number
6.3.1.20: Acid--ammonia (or amine) ligases (amide synthases)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

29-109 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6ZPT1

Entry ID Method Resolution Chain Position Source
AF-A6ZPT1-F1 Predicted AlphaFoldDB

No variants for A6ZPT1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A6ZPT1

No associated diseases with A6ZPT1

3 regional properties for A6ZPT1

Type Name Position InterPro Accession
domain Peptidase M1, membrane alanine aminopeptidase 237 - 437 IPR014782
domain Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal 470 - 612 IPR015211
domain Aminopeptidase N-like, N-terminal domain 27 - 206 IPR045357

Functions

Description
EC Number 6.3.1.20 Acid--ammonia (or amine) ligases (amide synthases)
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
lipoate-protein ligase activity Catalysis of the lipoylation of a protein in two steps: ATP + (R)-lipoate + a -N6-(lipoyl)lysine + AMP + diphosphate (overall reaction): (1) ATP + (R)-lipoate = lipoyl-AMP + diphosphate; (2) lipoyl-AMP + a -N6-(lipoyl)lysine + AMP.

1 GO annotations of biological process

Name Definition
protein lipoylation The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSMMLSNWAL SPRYVGQRNL IHCTTLFHTL TRWAKDADDK YHDINLMYEN MFTPSNDNVS
70 80 90 100 110 120
ILQDEGKSDY DTTKTSSMQE DISAFNKDLY NFYNIGYAKQ IMSASQLENI VKAKGRFVIQ
130 140 150 160 170 180
SLSTSPYYNL ALENYVFKNT PRAKRGPDNC RLVFYINDRC AVIGKNQNLW QEVDLAKLKS
190 200 210 220 230 240
KNFELLRRFS GGGTVLHDLG NVNYSYLTSR EKFETKFFNK MIIKWLNSLN PELRLDLNER
250 260 270 280 290 300
GDIIQDGFKI SGSAYKIAGG KAYHHATMLL NADLEQFSGL LEPSLPNNME WESSGVHSVK
310 320 330 340 350 360
SKIKNVGIIT PNQFIAVVSE RFQKTFKVDG EIPIYYCDEF KSINDEIKDA MNTLQSEQWK
370 380 390 400
YFSGPKFSVK IKDKGLTIKV EKGMIYDCDR NDLIGLEFKG FLENIDSYT