A6ZN61

PR
Gene name
FRE7 (SCY_4929)
Protein name
Ferric/cupric reductase transmembrane component 7
Names
Ferric-chelate reductase 7
Species
Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
KEGG Pathway
EC number
1.16.1.9: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

489-565 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6ZN61

Entry ID Method Resolution Chain Position Source
AF-A6ZN61-F1 Predicted AlphaFoldDB

No variants for A6ZN61

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A6ZN61

No associated diseases with A6ZN61

2 regional properties for A6ZN61

Type Name Position InterPro Accession
domain Far11/STRP, N-terminal 65 - 363 IPR012486
domain Far11/STRP, C-terminal 437 - 817 IPR021819

Functions

Description
EC Number 1.16.1.9 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
ferric-chelate reductase (NADPH) activity Catalysis of the reaction: 2 Fe3+-siderophore + NADP(+) + H(+) -> 2 Fe2+-siderophore + NADPH.
metal ion binding Binding to a metal ion.

3 GO annotations of biological process

Name Definition
copper ion transport The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
iron ion homeostasis Any process involved in the maintenance of an internal steady state of iron ions within an organism or cell.
iron ion transport The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIEERDLVLS NGIHCIADIH SELYARLKKE SQAVTPWVYQ KQYGKFVTYF VAVIIFLSLI
70 80 90 100 110 120
KKLAFMYYDS SEEFLPEKKN SPTTPSVFLA RIMTKLVAFN RYICYRKFPT LIFSYLGIPT
130 140 150 160 170 180
SVGTFLVVMA TTLYTLLYCF VPHPFYRPCA GFGSPPLSVR AGIMAISLVS FVFSLSGKIN
190 200 210 220 230 240
VIGWLVGLSY EKINIYHQWA SILCLFFSWV HVIPFLRQAR HEGGYERMHQ RWKASDMWRS
250 260 270 280 290 300
GVPPILFLNL LWLSSLPIAR RHFYEIFLQL HWILAVGFYI SLFYHVYPEL NSHMYLVATI
310 320 330 340 350 360
VVWFAQLFYR LAVKGYLRPG RSFMASTIAN VSIVGEGCVE LIVKDVDMAY SPGQHIFVRT
370 380 390 400 410 420
IDKDIISNHP FSIFPSAKYP GGIKMLIRAQ KGFSKRLYES NDDMKKILID GPYGGIERDI
430 440 450 460 470 480
RSFTNVYLIC SGSGISTCLP FLQKYGPILH KTNLEVITLD WVVRHREDIS WIRDEICTLS
490 500 510 520 530 540
NNLRQLFLDG TIVVRIYVCS DSTVPGIIKT FPQTADTASD QSDLAKREKD TEFGQDDTES
550 560 570 580 590 600
NSTFDKSNNE YKGLITIIPS KPDLNQVIND YQIGFRNCFI CSGSDSLRYT VGNSVAGLQA
610
KVFSNKNVEE CYLHSESFGY