A6V6F5
Gene name |
hmgA |
Protein name |
Homogentisate 1,2-dioxygenase |
Names |
HGDO, Homogentisate oxygenase, Homogentisic acid oxidase, Homogentisicase |
Species |
Pseudomonas aeruginosa (strain PA7) |
KEGG Pathway |
pap:PSPA7_3280 |
EC number |
1.13.11.5: With incorporation of two atoms of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A6V6F5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A6V6F5-F1 | Predicted | AlphaFoldDB |
No variants for A6V6F5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A6V6F5 | |||||
No associated diseases with A6V6F5
5 regional properties for A6V6F5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | ABC transporter-like, ATP-binding domain | 2 - 241 | IPR003439 |
| domain | AAA+ ATPase domain | 30 - 218 | IPR003593 |
| conserved_site | ABC transporter-like, conserved site | 141 - 155 | IPR017871 |
| domain | NIL domain | 265 - 340 | IPR018449 |
| domain | Methionine import ATP-binding protein MetN, ATP-binding domain | 1 - 233 | IPR041701 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.13.11.5 | With incorporation of two atoms of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| homogentisate 1,2-dioxygenase activity | Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+). |
| iron ion binding | Binding to an iron (Fe) ion. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| L-phenylalanine catabolic process | The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. |
| tyrosine catabolic process | The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNLDSTALAY | QSGFGNEFSS | EALPGALPVG | QNSPQKAPYG | LYAELLSGTA | FTMARSEARR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TWLYRITPSA | KHPPFRRLER | QIAGAELDAP | TPNRLRWDPL | ALPEQPTDFL | DGLLRMAANA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PGDKPAGVSI | YQYLANRSME | RCFYDADGEL | LLVPQLGRLR | LCTELGALQV | EPLEIAVIPR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GMKFRVELLD | GEARGYIAEN | HGAPLRLPDL | GPIGSNGLAN | PRDFLAPVAR | YEDSRQPLQL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VQKYLGELWA | CELDHSPLDV | VAWHGNNVPY | KYDLRRFNTI | GTVSFDHPDP | SIFTVLTSPT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SVHGLANIDF | VIFPPRWMVA | ENTFRPPWFH | RNLMNEFMGL | IQGAYDAKAG | GFVPGGASLH |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SCMSAHGPDA | ESCDKAIAAD | LRPHRIDQTM | AFMFETSQVL | RPSRAALETP | ALQNDYDACW |
| 430 | |||||
| ASLVSTFNPQ | RR |