A6UTE4

PR
Gene name
pyrG
Protein name
CTP synthase
Names
Cytidine 5'-triphosphate synthase, Cytidine triphosphate synthetase, CTP synthetase, CTPS, UTP--ammonia ligase
Species
Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)
KEGG Pathway
mae:Maeo_0174
EC number
6.3.4.2: Other carbon--nitrogen ligases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

421-542 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6UTE4

Entry ID Method Resolution Chain Position Source
AF-A6UTE4-F1 Predicted AlphaFoldDB

No variants for A6UTE4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A6UTE4

No associated diseases with A6UTE4

3 regional properties for A6UTE4

Type Name Position InterPro Accession
domain CTP synthase, N-terminal 2 - 264 IPR017456
domain Glutamine amidotransferase 301 - 533 IPR017926
domain CTP synthase GATase domain 290 - 532 IPR033828

Functions

Description
EC Number 6.3.4.2 Other carbon--nitrogen ligases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
CTP synthase activity Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate.
glutaminase activity Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3.
metal ion binding Binding to a metal ion.

2 GO annotations of biological process

Name Definition
'de novo' CTP biosynthetic process The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) from simpler components.
glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKFIFITGGV VSSLGKGITA SSIGRLLKAR GFKINMVKID PYLQIDAGTM SPYEHGEVFV
70 80 90 100 110 120
TDDGGETDLD LGNYERFVDI KLSANNNITT GKVYWSVLSK ERRGDYLGKT VQVIPHITNE
130 140 150 160 170 180
IKELIKSTGT NCDITIVEIG GTVGDIESLP FLEAIRQFKK DVGDNNVLYV HVSLLPYIKT
190 200 210 220 230 240
AGEIKTKPTQ HSVKELRGIG IQPNILVCRT EIPISEKTRE KLALFCDVEK DAVIEAKDAR
250 260 270 280 290 300
TIYEVPLNLE REGIAKLIIN KLKLNTNNSK PDLKEWRAMV DRIVNPLNEI TIGIVGKYIM
310 320 330 340 350 360
LKDAYTSITE SLVHAGAKHD TKVNIEWISS EELRDETYKE TMDKLVEDEK LDGILIPGGF
370 380 390 400 410 420
GERGIDGKVN ASKYARENNI PYLGICLGMQ CAVIDFARNV CNLKGANSTE FDEGAPFPVI
430 440 450 460 470 480
DYLPEQRDIE DKGGTMRLGE YKAILKEGSL AQKLYNEKEA FERHRHRYEV NPEYHDILTE
490 500 510 520 530 540
NGLIISGTSP DGKLAEFIEL DTLTHPYFIA TQAHPEFKSR PNKPHPLFDG LVKSALDKKL
KK