A6URK3

PR
Gene name
glyS
Protein name
Glycine--tRNA ligase
Names
Glycyl-tRNA synthetase, GlyRS
Species
Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)
KEGG Pathway
mvn:Mevan_1227
EC number
6.1.1.14: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

196-284 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6URK3

Entry ID Method Resolution Chain Position Source
AF-A6URK3-F1 Predicted AlphaFoldDB

No variants for A6URK3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A6URK3

No associated diseases with A6URK3

4 regional properties for A6URK3

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 158 - 461 IPR002314
domain Anticodon-binding 482 - 573 IPR004154
domain Aminoacyl-tRNA synthetase, class II 5 - 487 IPR006195
domain Glycyl-tRNA synthetase-like core domain 7 - 339 IPR033731

Functions

Description
EC Number 6.1.1.14 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glycine-tRNA ligase activity Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly).
protein dimerization activity The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.

1 GO annotations of biological process

Name Definition
glycyl-tRNA aminoacylation The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a glycine-accepting tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDKYDKIIDL TKRRGFLWNS FEIYGGIAGF FDYGPLGAIL KSSVINTWRK HYIINEGFYE
70 80 90 100 110 120
IDSPTVNPYE VLKASGHVEN FTDPLVECKS CLESFRADHI IEENIEVDTE GKTLNELQEM
130 140 150 160 170 180
IEKNNIKCPK CGGEFKEVNT FNLMFATSIG PGGKRAAFMR PETAQGIFIQ FKRISQFFRN
190 200 210 220 230 240
KLPYGAVQIG KAYRNEISPR QGVIRLREFT QAEAEFFIDS RKKENFEKFE SVKDLILPLL
250 260 270 280 290 300
PGKNQENESL SSEEKIVRMS LGDAVKNKII AHEAIAYYIA VTKKFLMDIG IDETKLRFRQ
310 320 330 340 350 360
HLPNEMAHYA ADCWDAELYT DRYGWIECVG IADRTDYDLR AHMKNSGEDL SVFVEFDESK
370 380 390 400 410 420
EIEVYEIELN YKLVGKTFKG DAKILEESLK ELSNDKMEEL IKTLKNNEKY ILKTCKRDFE
430 440 450 460 470 480
VLNEYLTVKK VKKNVTGEKI VPHVIEPSYG IDRITYCVIE HAFKEEDDRT LLAFVNTVSP
490 500 510 520 530 540
VKVGVFPLVN KEGMDEIAEN LKNKFRKNGI IAEYDDSGAI GRRYMRMDEI GTPFCVTVDG
550 560 570
ETLKDNTVTI RERDSREQFR IPLDGVVDYI KEKL