A6UDD3

PR
Gene name
hmgA
Protein name
Homogentisate 1,2-dioxygenase
Names
HGDO, Homogentisate oxygenase, Homogentisic acid oxidase, Homogentisicase
Species
Sinorhizobium medicae (strain WSM419) (Ensifer medicae)
KEGG Pathway
smd:Smed_2833
EC number
1.13.11.5: With incorporation of two atoms of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-90 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6UDD3

Entry ID Method Resolution Chain Position Source
AF-A6UDD3-F1 Predicted AlphaFoldDB

No variants for A6UDD3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A6UDD3

No associated diseases with A6UDD3

2 regional properties for A6UDD3

Type Name Position InterPro Accession
domain Homogentisate 1,2-dioxygenase, C-terminal domain 294 - 446 IPR046451
domain Homogentisate 1,2-dioxygenase, N-terminal domain 21 - 293 IPR046452

Functions

Description
EC Number 1.13.11.5 With incorporation of two atoms of oxygen
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
homogentisate 1,2-dioxygenase activity Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+).
iron ion binding Binding to an iron (Fe) ion.

2 GO annotations of biological process

Name Definition
L-phenylalanine catabolic process The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid.
tyrosine catabolic process The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLEKAERQRK AAPDQQRSAG YMPGFGNDFE TESLPGSLPQ GQNSPQKCNY GLYAEQLSGS
70 80 90 100 110 120
PFTAPRGTNE RSWLYRIRPS VRHTGRFTKI DYPHWKTAPH TPEHSLALGQ LRWSPLPAPS
130 140 150 160 170 180
QSLTFLQGIR TMTTAGDALT QVGMAAHAYA FNADMVDDYF FNADGELLIV PETGAFQVFT
190 200 210 220 230 240
ELGRIDVEPS EICLVPRGMM FKVTRLGDEK VWRGYICENY GAKFTLPDRG PIGANCLANP
250 260 270 280 290 300
RDFKTPVAAY EDKETPCRVQ VKWCGSFHTA EIAHSPLDVV AWHGNYAPYK YDLKTFSPVG
310 320 330 340 350 360
AILFDHPDPS IFTVLTAPSG EEGTANVDFV IFPPRWLVAE HTFRPPWYHR NIMSEFMGLI
370 380 390 400 410 420
HGRYDAKEEG FVPGGMSLHN MMLAHGPDFS GFEKASNGEL KPVKLDNTMA FMFETRFPQQ
430 440 450
LTTFAAELET LQDDYIDCWS GLERKFDGTP GIK