A6TVN9

PR
Gene name
addB
Protein name
ATP-dependent helicase/deoxyribonuclease subunit B
Names
ATP-dependent helicase/nuclease AddB
Species
Alkaliphilus metalliredigens (strain QYMF)
KEGG Pathway
amt:Amet_4176
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

581-653 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6TVN9

Entry ID Method Resolution Chain Position Source
AF-A6TVN9-F1 Predicted AlphaFoldDB

No variants for A6TVN9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A6TVN9

No associated diseases with A6TVN9

2 regional properties for A6TVN9

Type Name Position InterPro Accession
domain UvrD-like DNA helicase, C-terminal 273 - 586 IPR014017
domain PD-(D/E)XK endonuclease-like domain, AddAB-type 776 - 1115 IPR038726

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

7 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
5'-3' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA helicase activity Unwinding of a DNA helix, driven by ATP hydrolysis.
double-stranded DNA binding Binding to double-stranded DNA.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
double-strand break repair via homologous recombination The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAIRYIFGRA GRGKSYLALE EIKQKLQEEE DNKLFLLVPE QFTLQAERDL IRKQELTGMM
70 80 90 100 110 120
RAEVLSFTRL AHRVFSEVGG LTRVPINELG KNMILRKIAD ESLKELSIYQ SIAKQDGFIT
130 140 150 160 170 180
KLNELICEMK QHDITPTELT MELNEIEEET ILKRKLEDIT LLYQRFNNYL KGQYVDNEDH
190 200 210 220 230 240
VNLLIENIER VEFLEGAEIW IDGFQSFTPQ IIRVIEKLAQ KVANITITFT MELNAKEKDK
250 260 270 280 290 300
DLFHITQKTY LKVKTIAQKF NLDEEVINLD IEERKVLPKE KEIAHIEREF NTYPYKQYAD
310 320 330 340 350 360
EIANLEIFAG SNLYSEMENV AAQIIHLVRN RGYRWNDIAL VSGGLDQYSM ILKRVFEEYH
370 380 390 400 410 420
IPYFIDEKRS IMNNPMIELI LSSIEILSRG YQYEDVFSFL KTGFSDLTKD EVEQLENYVL
430 440 450 460 470 480
QYGIRGKAYS EPFTKGFEKK QIQQKDKEEG EKQIDEEKKE KYNELRMRFI APFAKFEKRI
490 500 510 520 530 540
YRKKKIGEIT KALFEFMKEL NIEDKLNQWI EELREEKYFE YVNENTQIWN KIMEIFDQLT
550 560 570 580 590 600
EILADESATL KEYGRILEAG FLACKVGVIP STIDQVLVGS IERSKSHDIK ALFVVGVNDG
610 620 630 640 650 660
VLPFGQEDGG ILLDHERESL VKKGISIGTT LESSLLEEQF MIYSAFSKPT EYLWVSYALA
670 680 690 700 710 720
DQEGKAMRQS ILIDRFKKLF KNLRIKSDVV NDVDRQLHLI TTPISTFKYM TENIRQNVDD
730 740 750 760 770 780
KAMADMWWDV YDWYSKEPTW EDRRKLMVKG LFHQNQITYI GENKAKSLYD NPIKSSVSRL
790 800 810 820 830 840
ERFANCPFSH FVTYGLRPKE RKEYQLSNPD IGRLFHDSME QFTKEMVNEE IQWKDLTKEK
850 860 870 880 890 900
NDELVEKVID EMVPDFEHGI MLSTHRYQYL VTRLKRISKR AMWTLTDHVK KGEFVPMGHE
910 920 930 940 950 960
IIFGLEGDVP PIIIELANGE KIYLEGRIDR VDLLNDEEDG NYVKIIDYKS GSKEFSLSDV
970 980 990 1000 1010 1020
YYGLQIQLMV YLDAILSSEE KKHQVEIHPG GIFYFKIDDP MVKTTEKVVE EVEKEINKKL
1030 1040 1050 1060 1070 1080
KMKGLVLKDV NIIKKMDRSI GRSSTIVPAG LTKDDEISKS SSALPEEDFK ALLNHVRRLV
1090 1100 1110 1120 1130 1140
KEIGEEMLKG NVKIEPFKKG GDTSCKYCDY IAICQFDNSF HDNQYKNIKE LKSDEVLERI
KKESQKKLE