A6TQM7

PR
Gene name
queA
Protein name
S-adenosylmethionine:tRNA ribosyltransferase-isomerase
Names
Queuosine biosynthesis protein QueA
Species
Alkaliphilus metalliredigens (strain QYMF)
KEGG Pathway
amt:Amet_2341
EC number
2.4.99.17: Transferring other glycosyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

137-208 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6TQM7

Entry ID Method Resolution Chain Position Source
AF-A6TQM7-F1 Predicted AlphaFoldDB

No variants for A6TQM7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A6TQM7

No associated diseases with A6TQM7

2 regional properties for A6TQM7

Type Name Position InterPro Accession
domain Proteasome component (PCI) domain 42 - 200 IPR000717
domain CSN8/PSMD8/EIF3K 62 - 187 IPR033464

Functions

Description
EC Number 2.4.99.17 Transferring other glycosyl groups
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity Catalysis of the reaction: S-adenosylmethionine + 7-(aminomethyl)-7-deazaguanosine-tRNA = adenine + methionine + epoxyqueuosine-tRNA. 7-(aminomethyl)-7-deazaguanosine-tRNA is also known as preQ1-tRNA, and epoxyqueuosine-tRNA as oQ-tRNA.

1 GO annotations of biological process

Name Definition
queuosine biosynthetic process The chemical reactions and pathways resulting in the formation of queuosines, a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKTNEFDFDL PDRLIAQTPL EKRDHSRLMV LDKNKQEIVH KHFYDITDYL NPGDCLVINN
70 80 90 100 110 120
TRVLPARLFG VKENTGGKME FLLLKRIDLN TWEVLVKPGK KAKIGSRFEF GEGILKAEVL
130 140 150 160 170 180
SMADEGARIV RFEYEGVFEE LLDQLGKMPL PPYITEELAD RERYQTVYSK HEGSSAAPTA
190 200 210 220 230 240
GLHFTPELLS EIKKKGINVV SITLHVGLGT FRPVKVDSLE NHEMHAEYYE ITEEAAQVIN
250 260 270 280 290 300
DTKKAGNRVF AVGTTSCRTL ESASTEKGKI EANKGWTNIF IFPGYQFKIL DGLITNFHLP
310 320 330 340
ESTLIMLVSA LLGKEKTLQA YKVAVDEQYR FFSFGDAMLI V