A6TCV9

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Klebsiella pneumoniae subsp pneumoniae (strain ATCC 700721 / MGH 78578)
KEGG Pathway
kpn:KPN_03029
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

397-470 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6TCV9

Entry ID Method Resolution Chain Position Source
AF-A6TCV9-F1 Predicted AlphaFoldDB

No variants for A6TCV9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A6TCV9

No associated diseases with A6TCV9

4 regional properties for A6TCV9

Type Name Position InterPro Accession
domain DHHA1 domain 733 - 871 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 653 - 696 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 7 - 556 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 3 - 709 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSKSTAEIRQ AFLDFFHSKG HQVVASSSLV PHNDPTLLFT NAGMNQFKDV FLGLDKRNYS
70 80 90 100 110 120
RATTAQRCVR AGGKHNDLEN VGYTARHHTF FEMLGNFSFG DYFKQDAIKY AWELLTGENW
130 140 150 160 170 180
FALPKEKLWV TVYETDDEAF DIWANEVGVP RERIIRIGDN KGAPFASDNF WQMGDTGPCG
190 200 210 220 230 240
PCTEIFFDHG DHIWGGPPGS PEEDGDRYIE IWNIVFMQFN RQADGTMEPL PKPSVDTGMG
250 260 270 280 290 300
LERIAAVLQH VNSNYDIDLF RDLIASVAKV TGATDLTNKS LRVIADHIRS CAFLVADGVI
310 320 330 340 350 360
PSNENRGYVL RRIIRRAIRH GNMLGAKDTF FWKLVAPLID VMGSAGDELK QQQAQVEQVL
370 380 390 400 410 420
KTEEEQFART LERGLALLDE ELSKLKGDTL DGETAFRLYD TYGFPVDLTA DVCRERNIKV
430 440 450 460 470 480
DEAGFEAAME EQRRRARESS GFGADYNAMI RVDGASEFKG YDHLELNGKV TALFIDGKAV
490 500 510 520 530 540
DSVSAGQEAV VILDQTPFYA ESGGQVGDKG ELKGAGFSFA VSDTQKYGQA IGHIGKVASG
550 560 570 580 590 600
SLKVGDAVQA DVDEARRHRI RLNHSATHLM HAALRQVLGT HVAQKGSLVN DKALRFDFSH
610 620 630 640 650 660
FEAMKPEEIR AVEDLVNAQI RRNLAIETNI MDIDAARASG AMALFGEKYD DRVRVLRMGD
670 680 690 700 710 720
FSTELCGGTH AARTGDIGLF RITSESGTAA GVRRIEAVTG EGAMAILHAQ SDQLNDIAQL
730 740 750 760 770 780
LKGDSHNLGE KVRAALERTR QLEKELQQLK EQAAAQESAN LSSKAEEING VKLLVSELTG
790 800 810 820 830 840
VEPKMLRTMV DDLKNQLGST IVVLATVADG KVSLIAGVSK DVTDRVKAGE LVGMVAQQVG
850 860 870
GKGGGRPDMA QAGGTDASAL PAALASVKGW VSAKL