A6TCC4

PR
Gene name
xseA
Protein name
Exodeoxyribonuclease 7 large subunit
Names
Exodeoxyribonuclease VII large subunit, Exonuclease VII large subunit
Species
Klebsiella pneumoniae subsp pneumoniae (strain ATCC 700721 / MGH 78578)
KEGG Pathway
kpn:KPN_02835
EC number
3.1.11.6: Exodeoxyribonucleases producing 5'-phosphomonoesters
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

83-155 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6TCC4

Entry ID Method Resolution Chain Position Source
AF-A6TCC4-F1 Predicted AlphaFoldDB

No variants for A6TCC4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A6TCC4

No associated diseases with A6TCC4

2 regional properties for A6TCC4

Type Name Position InterPro Accession
domain Exonuclease VII, large subunit, C-terminal 126 - 440 IPR020579
domain OB-fold nucleic acid binding domain 10 - 106 IPR025824

Functions

Description
EC Number 3.1.11.6 Exodeoxyribonucleases producing 5'-phosphomonoesters
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
exodeoxyribonuclease VII complex An enzyme complex that catalyzes exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield nucleoside 5'-phosphates; it prefers single-stranded DNA.

2 GO annotations of molecular function

Name Definition
exodeoxyribonuclease VII activity Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides.
nucleic acid binding Binding to a nucleic acid.

1 GO annotations of biological process

Name Definition
DNA catabolic process The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLPSQSPAIF TVSRLNQTVR LLLEREMGQV WISGEISNFS QPSSGHWYFT LKDDNAQVRC
70 80 90 100 110 120
AMFRNSNRRV TFRPQHGQQV LVRANITLYE PRGDYQIIVE SMQPAGEGLL QQKYEQLKAQ
130 140 150 160 170 180
LTAEGLFEQK HKQALPSPAH CVGVITSKTG AALHDILHVL RRRDPGLPVI IYPTSVQGDD
190 200 210 220 230 240
APGQIVRAIA LANARQECDV LIVGRGGGSL EDLWSFNDER VARAIFASQI PIVSAVGHET
250 260 270 280 290 300
DVTIADFVAD LRAPTPSAAA EIVSRNQQEL LRQLQSGQQR LEMAMDYFLA SRQRRFTQLF
310 320 330 340 350 360
HRLQQQHPQL RLARQQTALE RLRQRMRIAV ESQLKRAEQR QKRTVQRLNH YNPQPRIHRA
370 380 390 400 410 420
QSRIQQLEYR LAEIMRGRLS ERRERFGNAV THLEAVSPLA TLARGYSVTS VSDGTVLKQT
430 440 450 460
KQVKTGDLLT TRLKDGWVES EVKQIAPVKK TRARKPSPTK PAE