A6TBX2

PR
Gene name
nuoC
Protein name
NADH-quinone oxidoreductase subunit C/D
Names
NADH dehydrogenase I subunit C/D, NDH-1 subunit C/D
Species
Klebsiella pneumoniae subsp pneumoniae (strain ATCC 700721 / MGH 78578)
KEGG Pathway
kpn:KPN_02676
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6TBX2

Entry ID Method Resolution Chain Position Source
AF-A6TBX2-F1 Predicted AlphaFoldDB

No variants for A6TBX2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A6TBX2

No associated diseases with A6TBX2

4 regional properties for A6TBX2

Type Name Position InterPro Accession
domain NADH-quinone oxidoreductase, subunit D 331 - 602 IPR001135
domain NADH:ubiquinone oxidoreductase, 30kDa subunit 52 - 179 IPR001268
conserved_site NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site 254 - 265 IPR014029
conserved_site NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site 140 - 161 IPR020396

Functions

Description
EC Number
Subcellular Localization
  • Cell inner membrane ; Peripheral membrane protein ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
NADH dehydrogenase complex An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
NAD binding Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
NADH dehydrogenase (ubiquinone) activity Catalysis of the reaction: NADH + ubiquinone + 5 H(+)(in) <=> NAD(+) + ubiquinol + 4 H(+)(out).
quinone binding Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds.

1 GO annotations of biological process

Name Definition
respiratory electron transport chain A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVNNMTDLTA HDAAPAWQTR DHLDDPVIGE LRNRFGPDAF TVQPTRTGVP VVWVKREQLL
70 80 90 100 110 120
EVGDFLKKLP KPYVMLFDLH GMDERLRTHR DGLPAADFSV FYHLISIDRN RDIMLKVALS
130 140 150 160 170 180
ENDLHLPTFT KLFPNANWYE RETWEMFGIT FDGHPNLRRI MMPPTWEGHP LRKDYPARAT
190 200 210 220 230 240
EFDPFELTKA KQDLEMEALT FKPEEWGMKR GTDNEDFMFL NLGPNHPSAH GAFRIILQLD
250 260 270 280 290 300
GEEIVDCVPD IGYHHRGAEK MGERQSWHSY IPYTDRIEYL GGCVNEMPYV LAVEKLAGIT
310 320 330 340 350 360
VPDRVNVIRV MLSELFRINS HLLYISTFIQ DVGAMTPVFF AFTDRQKIYD LVEAITGFRM
370 380 390 400 410 420
HPAWFRIGGV AHDLPRGWDR LLREFLEWMP KRLDSYEKAA LRNTILKGRS VGVAAYTAKE
430 440 450 460 470 480
ALEWGTTGAG LRATGIDFDV RKWRPYSGYE NFDFEVPTGG GVSDCYTRVM LKVEELRQSL
490 500 510 520 530 540
RILQQCLDNM PEGPFKADHP LTTPPPKERT LQHIETLITH FLQVSWGPVM PANESFQMIE
550 560 570 580 590 600
ATKGINSYYL TSDGSTMSYR TRVRTPSFAH LQQIPSAIRG SLVSDLIVYL GSIDFVMSDV
DR