A6TBC7

PR
Gene name
hisA
Protein name
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
Names
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Species
Klebsiella pneumoniae subsp pneumoniae (strain ATCC 700721 / MGH 78578)
KEGG Pathway
kpn:KPN_02480
EC number
5.3.1.16: Interconverting aldoses and ketoses
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-63 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6TBC7

Entry ID Method Resolution Chain Position Source
AF-A6TBC7-F1 Predicted AlphaFoldDB

No variants for A6TBC7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A6TBC7

No associated diseases with A6TBC7

4 regional properties for A6TBC7

Type Name Position InterPro Accession
domain TonB-dependent receptor-like, beta-barrel 526 - 1065 IPR000531
repeat PT repeat 26 - 60 IPR006970
conserved_site TonB-dependent receptor, conserved site 1050 - 1067 IPR010917
domain TonB-dependent receptor, plug domain 80 - 189 IPR012910

Functions

Description
EC Number 5.3.1.16 Interconverting aldoses and ketoses
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Catalysis of the reaction: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.

1 GO annotations of biological process

Name Definition
histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIIPALDLID GTVVRLHQGD YGQQRDYGSD PLPRLQAYAA QGAKVLHLVD LTGAKDPAKR
70 80 90 100 110 120
QIPLLKSLVA GVDVPVQVGG GVRTEADVAA LLEAGVARVV VGSTAVKSPE EVKGWFKRFG
130 140 150 160 170 180
PERLVLALDV RIDADGNKQV AVSGWQENSG VTLEELVESY LPVGLQHVLC TDISRDGTLA
190 200 210 220 230 240
GSNVSLYEEV CARYPQVAFQ SSGGIGDLKD IAALRGTGVR GVIVGRALLE GKFNVTEAIQ
CWQNG