A6T742
Gene name |
rlmL |
Protein name |
Ribosomal RNA large subunit methyltransferase K/L |
Names |
|
Species |
Klebsiella pneumoniae subsp pneumoniae (strain ATCC 700721 / MGH 78578) |
KEGG Pathway |
kpn:KPN_00977 |
EC number |
2.1.1.173: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A6T742
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A6T742-F1 | Predicted | AlphaFoldDB |
No variants for A6T742
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A6T742 | |||||
No associated diseases with A6T742
4 regional properties for A6T742
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Ribosomal RNA large subunit methyltransferase K/L-like, FLD domain | 162 - 375 | IPR000241 |
| conserved_site | DNA methylase, N-6 adenine-specific, conserved site | 306 - 312 | IPR002052 |
| domain | THUMP domain | 23 - 154 | IPR004114 |
| domain | S-adenosylmethionine-dependent methyltransferase | 456 - 657 | IPR019614 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.173 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 23S rRNA (guanine(2445)-N(2))-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(2445) in 23S rRNA = N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| rRNA (guanine-N7-)-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N7-methylguanine. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNSLFASTAR | GLEELLKTEL | EGLGATDCQV | VQGGVHFQGD | TRLLYQSLMW | SRLASRIMLP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LGECRVYSDL | DLYLGVQAIP | WTEMFNPGAT | FAVHFSGLND | EIRNSQYGAL | KVKDAIVDSF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TRKNLPRPNV | DRESPDLRIN | VWLNKETAHI | SLDLSGEGLH | LRGYRDGTGM | APIKENLAAA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IVMRSGWVPG | TPLLDPMCGS | GTLLIEAAML | ATDRAPGLHR | GHWGFGGWAQ | HDDAIWKEVK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AEAQTRARQG | LAAYESRFYG | SDVDARVIER | ARRNARRAGI | GELIDFDVKD | VAQLNNPLPK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GPYGTVISNP | PYGERLESEP | ALIALHSLLG | RIMKSQFGGW | NLSVFSASPE | LLSCLQLRAD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KQFKAKNGPL | DCVQKNYHLA | ESEGGKPAML | AEDFANRLRK | NLKKFEKWAR | QEGIECYRLY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DADLPEYNVA | IDRYADWVVV | QEYAPPKTVD | AHKARQRLFD | IIAATIAVLD | MAPNKLVLKT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RERQKGKNQY | QKMAEKGDFI | EVQEYNARLW | VNLTDYLDTG | LFLDHRIARR | MLGQMSKGKD |
| 550 | 560 | 570 | 580 | 590 | 600 |
| FLNLFSYTGS | ASVHAGLGGA | RSTTTVDMSR | TYLEWAERNL | RLNGLTGRAH | RLMQADVLGW |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LRESTEQFDL | IFIDPPTFSN | SKRMEDAFDV | QRDHIRLMTD | LKRLLRKGGT | IMFSNNKRGF |
| 670 | 680 | 690 | 700 | ||
| RMDHDGLAAL | GLKAQEISQK | TLSQDFARNR | QIHNCWLITA | A |