A6T6L5

PR
Gene name
bioB
Protein name
Biotin synthase
Names
Species
Klebsiella pneumoniae subsp pneumoniae (strain ATCC 700721 / MGH 78578)
KEGG Pathway
kpn:KPN_00800
EC number
2.8.1.6: Sulfurtransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

273-346 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6T6L5

Entry ID Method Resolution Chain Position Source
AF-A6T6L5-F1 Predicted AlphaFoldDB

No variants for A6T6L5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A6T6L5

No associated diseases with A6T6L5

3 regional properties for A6T6L5

Type Name Position InterPro Accession
domain Elp3/MiaA/NifB-like, radical SAM core domain 43 - 255 IPR006638
domain Radical SAM 38 - 256 IPR007197
domain Biotin and thiamin synthesis-associated domain 220 - 312 IPR010722

Functions

Description
EC Number 2.8.1.6 Sulfurtransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
2 iron, 2 sulfur cluster binding Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
biotin synthase activity Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H(+).
iron ion binding Binding to an iron (Fe) ion.

1 GO annotations of biological process

Name Definition
biotin biosynthetic process The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAHQPRWTMS QVTELFNKPL IDLLFEAQQI HRQHFDPRQV QVSTLLSIKT GACPEDCKYC
70 80 90 100 110 120
PQSARYKTGL EAERLMEVEQ VLESARQAKN AGSTRFCMGA AWKNPNDRDM PYLEQMVKGV
130 140 150 160 170 180
KALGLESCMT LGTLTDSQAQ RLAEAGLDYY NHNLDTSPEF YGNIITTRTY QERLDTLDKV
190 200 210 220 230 240
RDAGIKVCSG GIVGLGESVK DRAGLLLQLA NLPTPPESVP INMLVKVKGT PLADNDDVDA
250 260 270 280 290 300
FDFIRTIAIA RIMMPTSYVR LSAGREQMNE QTQAMCFMAG ANSIFYGCKL LTTPNPEEDK
310 320 330 340
DLQLFRKLGI NPQQTAVLEG DNEQQQRLEQ ALLTPDTEEY YNAAAL