A6T512

PR
Gene name
rnhA
Protein name
Ribonuclease H
Names
RNase H
Species
Klebsiella pneumoniae subsp pneumoniae (strain ATCC 700721 / MGH 78578)
KEGG Pathway
kpn:KPN_00229
EC number
3.1.26.4: Endoribonucleases producing 5'-phosphomonoesters
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

104-155 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6T512

Entry ID Method Resolution Chain Position Source
AF-A6T512-F1 Predicted AlphaFoldDB

No variants for A6T512

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A6T512

No associated diseases with A6T512

1 regional properties for A6T512

Type Name Position InterPro Accession
domain Ribonuclease H domain 1 - 142 IPR002156

Functions

Description
EC Number 3.1.26.4 Endoribonucleases producing 5'-phosphomonoesters
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
magnesium ion binding Binding to a magnesium (Mg) ion.
nucleic acid binding Binding to a nucleic acid.
RNA-DNA hybrid ribonuclease activity Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.

1 GO annotations of biological process

Name Definition
RNA catabolic process The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLKQVEIFTD GSCLGNPGPG GYGAIMRYRQ HEKTFSAGYR LTTNNRMELM AAIVALEALK
70 80 90 100 110 120
EHCEVVLSTD SQYVRQGITQ WIHNWKKRGW KTAEKKPVKN VDLWQRLDAA LGQHKIKWEW
130 140 150
VKGHAGHPEN ERCDELARAA ASHPTLDDVG YLPES