Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A6RPB6
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A6RPB6-F1 | Predicted | AlphaFoldDB |
No variants for A6RPB6
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A6RPB6 | |||||
No associated diseases with A6RPB6
1 regional properties for A6RPB6
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Large-conductance mechanosensitive channel, conserved site | 11 - 24 | IPR019823 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP-dependent DNA damage sensor activity | A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis. |
| mismatched DNA binding | Binding to a double-stranded DNA region containing one or more mismatches. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| mismatch repair | A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGKPNSTPAK | TQKSISSFFA | PKSSQKPQDS | SSPPASKAPG | NLDDADSNEG | TNEDAKITGN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RLKRVLEEDE | NGGNTGAKER | PSKRAKSVEV | EEEDNESYAL | PAADSRKTSS | SLTRGKSKPS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LRTNKYMFSG | SSQRATESLI | EEEPEDELEK | ARKVELHKKF | VKKLGHPDSL | RRIIHEDDAA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LEVGDEEGEE | DEEAPAPVKT | KKKGAKTGKL | TPMELQVIDI | KRKHMDTLLI | VEVGYKFKFF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GEDARTAAKV | LSIVCIPGKF | RFDEHPSESH | LNYFASASIP | VHRLPVHAKR | LVAAGYKIGI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VRQTETAALK | KAGDNRNAPF | VRKLTNVYTK | GTYIDDIDGL | DTTDAPSGGA | PATGYLLCIT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ETKAKGWGTD | EKVEVGILAV | QPATGDVIYD | NFEDGFMRGE | LETRLLHIAP | CELLIVGELT |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KATDKLVQHL | SGSSTNVFGD | RIRVERVGKS | KTMAAESYSR | VAQFYADKLK | AHQSSNNARE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| QELLEKVLKL | TEPVTICLSA | MITHMTEYGL | EHVFDLTKYF | QSFSARSHML | LNGNTLTSLE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IYTNQTDYTQ | KGSLFWTLDK | TQTKFGQRLL | RKWVGRPLLD | KQRLEERVAA | VEELKDNANT |
| 610 | 620 | 630 | 640 | 650 | 660 |
| PKVDKLNATL | REVRSDLERS | LLRIYYGKCT | RPELLTVLQT | MQRIANEFAH | VKTPSDAGFE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SIALNEAVAS | LPAIGEIVIS | FLDKINAQAA | RNDDKYAFFL | EHYETEAIGD | HKCGIGAVEQ |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DLEAHRMVAA | TKLSKKTPVT | YVTIAGIEYL | IEVPNTDLKN | VPASWAKISG | TKKMSRFHTP |
| 790 | 800 | 810 | 820 | 830 | 840 |
| EVIKFLRERD | QHKESLSSAC | DAAFSTFLSE | ISTHYALIRD | TISHLATLDC | LLSLATVASL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| PGYCKPTFTS | STEISVIGGR | HPMVEQLLPS | AYIPNDTSLS | TSPDHTRALL | LTGPNMGGKS |
| 910 | 920 | 930 | 940 | 950 | 960 |
| SYVRQVALIS | ILAQIGSYVP | AESARLGLLD | GIYTRMGAYD | SLFTAQSTFM | VELSETASIL |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| KSAGPRSLVI | LDELGRGTST | HDGVAIAEAV | LDWVVRETKC | LCLFITHYQT | LASVARGFEK |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| GKELRNVHMK | FTAERNGRRV | SNADADKDNE | DFDEEITFLY | EVGEGVAHRS | YGLNVARLAR |
| 1090 | 1100 | 1110 | 1120 | 1130 | |
| VPKSVLDTAA | SKSRELETQV | KQKKLLGLSN | MISNVLENGT | DQLDQLIIGM | EQL |