A6R3R5
Gene name |
TIF1 (TIF41, HCAG_04273) |
Protein name |
ATP-dependent RNA helicase eIF4A |
Names |
Eukaryotic initiation factor 4A, eIF-4A, Translation initiation factor 1 |
Species |
Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum) |
KEGG Pathway |
aje:HCAG_04273 |
EC number |
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A6R3R5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A6R3R5-F1 | Predicted | AlphaFoldDB |
No variants for A6R3R5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A6R3R5 | |||||
No associated diseases with A6R3R5
1 regional properties for A6R3R5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | ITPR-interacting domain | 128 - 292 | IPR029325 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.6.4.13 | Acting on ATP; involved in cellular and subcellular movement |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASNDKGLEE | IPEGQIESNY | DEITDSFDAM | NLRAELLRGV | YAYGFERPSA | IQQRAIMPVI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KGSDVIAQAQ | SGTGKTATFS | ISALQKVDTN | LKACQALILA | PTRELAQQIQ | KVVVAIGDFM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SIECHACIGG | ISVREDMKAL | QDGPQVVVGT | PGRVHDMIQR | RVLKTDHMKM | FVLDEADEML |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SHGFTEQIYD | IFQFLPQSTQ | VVLLSATMPQ | DVLEVTTKFM | RDPVRILVKK | AELTLEGIKQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FYIAVEKEEW | KLDTLSDLYE | TVTITQAVIF | CNTRRKVDWL | TDKLTARDFT | VSAMHGDMEQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QQRDVIMKEF | RSGSSRVLIA | TDLLARGIDV | QQVSLVINYD | LPANRENYIH | RIGRGGRFGR |
| 370 | 380 | ||||
| KGVAINFVTA | DDNGRTRKAK | RKKGI |