A6QAK6

PR
Gene name
purL
Protein name
Phosphoribosylformylglycinamidine synthase subunit PurL
Names
FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit II, FGAR amidotransferase II, FGAR-AT II, Glutamine amidotransferase PurL, Phosphoribosylformylglycinamidine synthase subunit II
Species
Sulfurovum sp (strain NBC37-1)
KEGG Pathway
sun:SUN_1565
EC number
6.3.5.3: Carbon--nitrogen ligases with glutamine as amido-N-donor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

194-270 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6QAK6

Entry ID Method Resolution Chain Position Source
AF-A6QAK6-F1 Predicted AlphaFoldDB

No variants for A6QAK6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A6QAK6

No associated diseases with A6QAK6

5 regional properties for A6QAK6

Type Name Position InterPro Accession
domain PurM-like, C-terminal domain 208 - 359 IPR010918-1
domain PurM-like, C-terminal domain 577 - 711 IPR010918-2
domain PurM-like, N-terminal domain 87 - 194 IPR016188-1
domain PurM-like, N-terminal domain 458 - 562 IPR016188-2
domain Phosphoribosylformylglycinamidine synthase, linker domain 14 - 53 IPR041609

Functions

Description
EC Number 6.3.5.3 Carbon--nitrogen ligases with glutamine as amido-N-donor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
magnesium ion binding Binding to a magnesium (Mg) ion.
phosphoribosylformylglycinamidine synthase activity Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate.

1 GO annotations of biological process

Name Definition
'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSQPVENLDE VLKNHKLSKE EYEDILRILD GRHPNIVEIG IFSAMWSEHC SYKSSKKYLN
70 80 90 100 110 120
GFPTKAPWVI QGPGENAGVI DIGDGMAAVF KMESHNHPSF IEPFQGAATG VGGILRDIFT
130 140 150 160 170 180
MGARPVANLN ALRFGRVRGD SDINKYQRHL VRGVVDGIGS YGNCMGVPTI GGEVSFDESY
190 200 210 220 230 240
NGNILVNAFS LGLVKSDEIF LGVASGIGNP VMYVGSKTGR DGLGGAVMSS DSFTEESKSL
250 260 270 280 290 300
RPTVQVGDPF TEKLLLEACL ELFKTDAIIG IQDMGAAGLT SSAFEMAGKT GAGLIMHLDK
310 320 330 340 350 360
VPAREEGMTP YDFMLSESQE RMLICAKKGR EQEIIDIFEK WELDVAVIGE VTDTERMELF
370 380 390 400 410 420
WYGDKVCDMP IAPVSEEAPI LDRPVARPAY LNEVIAKTVD DYAKVDDQEA YEKLLAPLEV
430 440 450 460 470 480
VDKAWVYNQY DSMVQTNTTK HPGSLDASCI RIKENGRALA MSSDCNPRYC YIDPKGGAAL
490 500 510 520 530 540
AVVESGRNVA MSGARPLSIT DCLNYGNPEN PEVMWQFAQG CEGIKEACLE LNTPVVSGNV
550 560 570 580 590 600
SLYNETNGVS VFPTPAIAMV GLNDDQNKVL PSVFQHEGNN IVLIGETKGE FGGSLYIKEL
610 620 630 640 650 660
FGETVGTLPS FDYKTELKLW ELVIEANKIG LLESAKDVNV GGIAIALSKM AAVSSKGITV
670 680 690 700 710 720
KASVSNSRDI FDESQSRALL EVADADLEEL LDMAAGLGLK AEVIGKIGGE EVKVNDVALP
730
LEKVKDVYFN TFKRTIEQDL