A6Q3R4

PR
Gene name
valS
Protein name
Valine--tRNA ligase
Names
Valyl-tRNA synthetase, ValRS
Species
Nitratiruptor sp (strain SB155-2)
KEGG Pathway
nis:NIS_1013
EC number
6.1.1.9: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

788-871 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6Q3R4

Entry ID Method Resolution Chain Position Source
AF-A6Q3R4-F1 Predicted AlphaFoldDB

No variants for A6Q3R4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A6Q3R4

No associated diseases with A6Q3R4

5 regional properties for A6Q3R4

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 47 - 58 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 15 - 574 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 616 - 754 IPR013155
domain Valyl-tRNA synthetase, tRNA-binding arm 811 - 869 IPR019499
domain Valyl tRNA synthetase, anticodon-binding domain 573 - 697 IPR033705

Functions

Description
EC Number 6.1.1.9 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
valine-tRNA ligase activity Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSKATKYDPK KVERQFYQIW ETRGYFETDG NKKIQNGKTF CIMMPPPNVT GRLHIGHALT
70 80 90 100 110 120
FTLQDIMVRY KRMDGYETLW QPGTDHAGIA TQNVVEKQLL SKGIKKEEIG REKFLEYVWK
130 140 150 160 170 180
WKEESGNAIV TQLRLLGVSP AWSRERFTMD KGLKNAVREA FVNLYYEGLI VKGNYMINWC
190 200 210 220 230 240
THDGALSDIE VEYEEKEGAL YHIKYPIVGS DEYLVVATTR PETYFGDTAV MVNPNDERYK
250 260 270 280 290 300
HLIGKKVRLP LINREIPIIA DEHVDMEFGT GAVKVTPAHD PNDYEVGKRH NLPFITIFDE
310 320 330 340 350 360
NGILNEEAGE FAGIERLEAR KKVVEKLEQE GFIEKIEPHK HQVGHCYRCG NVVEPYISPQ
370 380 390 400 410 420
WFVKAEIAKE AVKKANEGET KFYPPQWLNN FNAWMRELRD WCISRQLWWG HRIPVWYCRA
430 440 450 460 470 480
CGHEWASKKE HEESCPKCGS TDIYQDPDVL DTWFSSALWP FSTLGWGNGD WGKGVKWFED
490 500 510 520 530 540
DLKKFYPNDL LITGFDILFF WVARMMMMGE HFLHKLPFKD VYLHALVRDE HGQKMSKSRG
550 560 570 580 590 600
NVIDPIDTIE EYSADALRFT LAALAVQGRD IRLSKERLEL YRNFTNKLYN AARFLQIHQE
610 620 630 640 650 660
KFDDLQNIQI KTDLGKYILS RFGLAIQEVR NNLNSYRFND AATTLYRFLW GEFCDWGIEL
670 680 690 700 710 720
SKVNKDAIAE LGAIFKESMK LLHPFMPFIT EFLYQELSGT SIEENESIMI QPYPKAAPID
730 740 750 760 770 780
EEIMKRFETI IDAIVSIRRA KALIDMANKT IPKVLIKGDL EESAKAYISK LAKVETIEFV
790 800 810 820 830 840
SEPAENAVTD IGNYVEVFIP LEGIDLTPIL NRLNKQKEKL QKEIDKLSRM LSNENFVKNA
850 860 870
PQAVVEQNRA ALAEAQNRLA TIEEELARLT R