AiPD: Autoinhibited Protein Database

A6NFY4

Gene name	NEMP2 (TMEM194B)
Protein name	Nuclear envelope integral membrane protein 2
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:100131211
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

364-417 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

364-417 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for A6NFY4

Entry ID	Method	Resolution	Chain	Position	Source
AF-A6NFY4-F1	Predicted				AlphaFoldDB

277 variants for A6NFY4

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA2028766 rs13412879	2	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1368797351 CA349997514	2	G>V		No	ClinGen gnomAD
rs1389754083 CA349997505	4	R>C		No	ClinGen TOPMed
CA349997502 rs1397432487	4	R>H		No	ClinGen gnomAD
rs1397432487 COSM4139140 CA349997504	4	R>L	ovary [Cosmic]	No	ClinGen cosmic curated gnomAD
CA349997492 rs1466043455 CA349997493	6	G>R		No	ClinGen TOPMed gnomAD
CA349997483 rs1173922195	7	R>L		No	ClinGen gnomAD
CA349997486 rs1377027158	7	R>W		No	ClinGen TOPMed gnomAD
rs1434651758 CA349997465	9	W>C		No	ClinGen gnomAD
CA349997464 rs1267878441	10	L>M		No	ClinGen gnomAD
CA349997461 rs1178239584	10	L>P		No	ClinGen gnomAD
rs1038101322 CA62950525	11	L>P		No	ClinGen Ensembl
rs940321097 CA62950523	13	W>*		No	ClinGen TOPMed gnomAD
rs897579732 CA62950524	13	W>G		No	ClinGen TOPMed gnomAD
CA349997431 rs1263779167	16	P>S		No	ClinGen TOPMed gnomAD
rs1174997639 CA349997413	18	A>V		No	ClinGen TOPMed
CA349997403 rs1475519287	20	L>P		No	ClinGen TOPMed
rs1356511026 CA349997386	23	R>H		No	ClinGen TOPMed
CA349997385 rs1356511026	23	R>P		No	ClinGen TOPMed
rs755350873 CA62950520	24	G>R		No	ClinGen TOPMed gnomAD
rs755350873 CA349997382	24	G>W		No	ClinGen TOPMed gnomAD
CA2028764 rs756949365	25	E>K		No	ClinGen ExAC gnomAD
CA62950519 rs370393421	26	A>V		No	ClinGen TOPMed gnomAD
CA349997361 rs1374240226	27	A>V		No	ClinGen TOPMed gnomAD
CA349997349 rs1215536715	29	A>V		No	ClinGen TOPMed
rs1273350007 CA349997342	31	L>I		No	ClinGen TOPMed
rs1485707826 CA349997330	32	S>*		No	ClinGen TOPMed
rs1228594458 CA349997329	33	V>I		No	ClinGen TOPMed gnomAD
CA62949546 rs1046582006	34	R>C		No	ClinGen TOPMed gnomAD
CA349996660 rs1375260816	34	R>H		No	ClinGen TOPMed
rs1375260816 CA349996657	34	R>L		No	ClinGen TOPMed
CA349996642 rs1489471321	35	R>S		No	ClinGen gnomAD
rs747996696 CA62949545	35	R>T		No	ClinGen Ensembl
CA2028751 rs774588641	36	C>Y		No	ClinGen ExAC gnomAD
CA349996609 rs1407836367	38	A>G		No	ClinGen TOPMed
rs1287636601 CA349996597	39	L>S		No	ClinGen TOPMed
CA62949544 rs979081073	44	L>*		No	ClinGen TOPMed
rs1205292575 CA349996504	45	I>V		No	ClinGen gnomAD
rs1355212851 CA349996486	46	R>I		No	ClinGen TOPMed gnomAD
CA349996480 rs769096217	47	T>A		No	ClinGen TOPMed
rs764081214 CA349996475	47	T>K		No	ClinGen ExAC TOPMed gnomAD
rs764081214 CA2028750	47	T>M		No	ClinGen ExAC TOPMed gnomAD
rs769096217 CA62949543	47	T>P		No	ClinGen TOPMed
CA349996456 rs1355595243	48	S>F		No	ClinGen gnomAD
rs1277483427 CA349996391	53	Y>H		No	ClinGen gnomAD
rs775360448 CA2028748	53	Y>S		No	ClinGen ExAC gnomAD
CA349996289 rs1342083029	56	N>S		No	ClinGen TOPMed gnomAD
CA349996273 rs1318733548	57	Q>L		No	ClinGen TOPMed gnomAD
rs984493198 CA62949542	58	N>T		No	ClinGen TOPMed
rs1413180352 CA349996243	60	Q>*		No	ClinGen TOPMed
rs1404949654 CA349996236	60	Q>R		No	ClinGen gnomAD
CA349996198 rs1388876501	63	W>*		No	ClinGen gnomAD
TCGA novel	66	I>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA62949541 rs778767023	66	I>V		No	ClinGen TOPMed gnomAD
rs1423085905 CA349996126	67	W>R		No	ClinGen gnomAD
CA349996093 rs1353033870	69	T>A		No	ClinGen TOPMed
CA62948990 rs780609640	74	I>T		No	ClinGen TOPMed gnomAD
CA349995920 rs1483545296	76	S>T		No	ClinGen TOPMed
CA62948989 rs946147900	78	G>A		No	ClinGen TOPMed gnomAD
CA349995905 rs1200479857	79	L>M		No	ClinGen gnomAD
CA349995898 rs1468646412	80	F>V		No	ClinGen gnomAD
CA349995892 rs1574302324	81	R>G		No	ClinGen Ensembl
rs184187225 CA2028737	83	V>I		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs756587406 CA2028736	85	I>V		No	ClinGen ExAC TOPMed gnomAD
CA2028735 rs370283521	86	A>T	Variant assessed as Somatic; 6.258e-05 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA2028733 rs757547291	90	N>S		No	ClinGen ExAC gnomAD
rs751789976 CA2028732	94	P>T		No	ClinGen ExAC gnomAD
TCGA novel	95	E>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2028731 rs764377239	98	L>Q		No	ClinGen ExAC gnomAD
rs1029279177 CA62948987	101	I>V		No	ClinGen TOPMed gnomAD
rs1449058850 CA349995744	102	K>R		No	ClinGen gnomAD
CA349995719 rs974809341	106	H>N		No	ClinGen TOPMed gnomAD
rs963039707 CA62948985	106	H>Q		No	ClinGen TOPMed
CA349995716 rs1413280262	106	H>R		No	ClinGen gnomAD
CA62948986 rs974809341	106	H>Y		No	ClinGen TOPMed gnomAD
rs775621267 CA2028728	107	N>K		No	ClinGen ExAC TOPMed gnomAD
rs765360219 CA2028727	108	F>L		No	ClinGen ExAC gnomAD
rs759579269 CA2028726	112	K>E		No	ClinGen ExAC gnomAD
CA349995672 rs1325489773	112	K>N		No	ClinGen TOPMed gnomAD
rs1212122753 CA349995668	113	E>*		No	ClinGen TOPMed
rs1254199484 CA349995665	113	E>G		No	ClinGen TOPMed
rs1485034731 CA349995658	114	S>C		No	ClinGen TOPMed
CA2028724 rs192032539	116	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs746806470 CA349995603	122	N>I		No	ClinGen ExAC gnomAD
rs866635317 CA62948984	122	N>K		No	ClinGen Ensembl
CA2028723 rs746806470	122	N>S		No	ClinGen ExAC gnomAD
CA349995589 rs1174519690	124	Y>*		No	ClinGen TOPMed
rs1416570431 CA349995592	124	Y>C		No	ClinGen TOPMed
CA62948982 rs1022332083	125	R>G		No	ClinGen Ensembl
CA349995586 rs1375409527	125	R>T		No	ClinGen TOPMed
CA349995577 rs1234773458	126	E>G		No	ClinGen gnomAD
rs1352775371 CA349995551	130	F>I		No	ClinGen gnomAD
CA349995496 rs1374077122	138	I>V		No	ClinGen TOPMed gnomAD
CA2028722 rs558356478	139	F>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA349995472 rs1446412045	141	Y>S		No	ClinGen gnomAD
rs1314078107 CA349995447	142	M>I		No	ClinGen gnomAD
CA349995454 rs1361430176	142	M>V		No	ClinGen gnomAD
CA349995428 rs1275715401	144	H>D		No	ClinGen TOPMed
rs771722181 CA2028721	145	V>M		No	ClinGen ExAC TOPMed gnomAD
CA2028720 rs747659845	147	R>*		No	ClinGen ExAC gnomAD
CA349995384 rs866695882	147	R>L		No	ClinGen TOPMed gnomAD
CA62948981 COSM3425880 rs866695882	147	R>Q	large_intestine Variant assessed as Somatic; 5.976e-05 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
rs1477457506 CA349995307	150	M>L		No	ClinGen gnomAD
rs1477457506 CA349995308	150	M>V		No	ClinGen gnomAD
CA349995260 rs1403807121	152	F>L		No	ClinGen TOPMed
CA349995252 rs1325522958	153	K>E		No	ClinGen TOPMed
rs759632181 CA2028708	156	L>F		No	ClinGen ExAC gnomAD
CA2028707 rs753883894	156	L>P		No	ClinGen ExAC TOPMed gnomAD
rs1559160877 CA349995160	160	A>T		No	ClinGen Ensembl
rs760426050 CA2028703	162	V>G		No	ClinGen ExAC TOPMed gnomAD
rs1219730025 CA349995118	163	F>L		No	ClinGen gnomAD
CA2028699 rs199878689	164	L>F		No	ClinGen ExAC TOPMed gnomAD
rs146103983 CA62948966	165	F>L		No	ClinGen 1000Genomes
rs201105504 CA62948965	165	F>L		No	ClinGen ExAC gnomAD
rs202060494 CA2028698	165	F>Y		No	ClinGen ExAC gnomAD
CA349995057 rs974990327	167	Y>*		No	ClinGen TOPMed gnomAD
rs773922713 CA2028696	167	Y>F		No	ClinGen ExAC gnomAD
rs748795957 CA2028694	168	A>G		No	ClinGen ExAC
rs768165225 CA2028695	168	A>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs200187690 CA2028692 CA62948963	169	R>S		No	ClinGen ExAC TOPMed gnomAD
CA62948962 rs978324856	170	T>N		No	ClinGen TOPMed gnomAD
rs1318989948 CA349995047	170	T>P		No	ClinGen TOPMed
CA62948961 rs968313866	171	L>M		No	ClinGen TOPMed
rs778232592 CA2028690	175	P>S		No	ClinGen ExAC TOPMed gnomAD
rs758625606 CA2028689	178	Y>C		No	ClinGen ExAC gnomAD
CA62948861 rs758625606	178	Y>S		No	ClinGen ExAC gnomAD
CA2028688 rs571200788	181	S>L		No	ClinGen ExAC TOPMed gnomAD
rs1182625912 CA349994592	182	G>A		No	ClinGen TOPMed
rs1299661337 CA349994589	183	T>A		No	ClinGen gnomAD
rs182544907 CA62948859	186	G>A		No	ClinGen 1000Genomes TOPMed gnomAD
rs1420293738 CA762368715	186	G>F		No	ClinGen TOPMed
rs1372752572 CA349994572	186	G>R		No	ClinGen TOPMed gnomAD
rs1372752572 CA349994571	186	G>S		No	ClinGen TOPMed gnomAD
rs1410437053 CA349994562	188	L>I		No	ClinGen TOPMed
CA349994560 rs1359762826	188	L>P		No	ClinGen TOPMed gnomAD
CA349994539 rs1454732883	191	L>S		No	ClinGen Ensembl
rs1299797384 CA349994517	194	V>A		No	ClinGen gnomAD
rs940041383 CA62948855	198	V>G		No	ClinGen Ensembl
rs1559159870 CA349994481	200	R>T		No	ClinGen Ensembl
rs908603941 CA62948854	201	F>S		No	ClinGen TOPMed gnomAD
rs1455711855 CA349994463	202	I>M		No	ClinGen gnomAD
CA349994467 rs1293457123	202	I>V		No	ClinGen TOPMed
CA62948853 rs984156058	203	P>L		No	ClinGen TOPMed gnomAD
rs1327437781 CA349994418	207	T>N		No	ClinGen TOPMed
CA349994401 rs1301069983	209	W>*		No	ClinGen gnomAD
CA2028683 rs766276124	210	A>P		No	ClinGen ExAC gnomAD
CA2028682 rs766276124	210	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA349994383 rs1375910897	212	M>I		No	ClinGen gnomAD
CA62948736 rs899819504	212	M>T		No	ClinGen TOPMed gnomAD
CA62948735 rs1018301388	214	G>D		No	ClinGen TOPMed gnomAD
rs1235134041 CA349994363	215	C>W		No	ClinGen TOPMed
CA349994354 rs1282635543	216	W>C		No	ClinGen TOPMed
CA349994330 rs1438082873	220	V>A		No	ClinGen gnomAD
CA62948734 rs534564363	220	V>I		No	ClinGen 1000Genomes TOPMed
CA349994324 rs1200134945	221	Y>C		No	ClinGen TOPMed
CA349994314 rs1008728641	222	I>M		No	ClinGen TOPMed gnomAD
CA349994316 rs1182662166	222	I>T		No	ClinGen gnomAD
rs1379992013 CA349994319	222	I>V		No	ClinGen gnomAD
rs891251532 CA62948732	223	V>L		No	ClinGen gnomAD
rs200073518 CA2028681	224	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs750284004 CA2028680	232	W>R		No	ClinGen ExAC TOPMed gnomAD
CA2028679 rs767344371	234	W>G		No	ClinGen ExAC gnomAD
rs757244837 CA62948731	235	Y>*		No	ClinGen Ensembl
rs1261925234 CA349994224	235	Y>C		No	ClinGen gnomAD
rs761455719 CA2028678	235	Y>D		No	ClinGen ExAC gnomAD
rs900915920 CA62948730	236	E>G		No	ClinGen TOPMed gnomAD
rs1239115762 CA349994208	237	N>K		No	ClinGen gnomAD
rs1339409522 CA349994193	239	I>M		No	ClinGen gnomAD
rs1291361110 CA349994175	242	L>S		No	ClinGen gnomAD
rs890216513 CA62948574	245	V>I		No	ClinGen Ensembl
rs185699992 CA62948573	254	V>L		No	ClinGen 1000Genomes
rs1051224178 CA62948572	257	Y>C		No	ClinGen Ensembl
rs1355023786 CA349994062	257	Y>H		No	ClinGen gnomAD
CA349994055 rs1202656871	258	K>E		No	ClinGen TOPMed
CA349994056 rs1202656871	258	K>Q		No	ClinGen TOPMed
CA349994008 rs1053351879	265	D>H		No	ClinGen TOPMed gnomAD
COSM3425878 rs1053351879 CA62948569	265	D>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed gnomAD
CA62948568 rs536901665	268	R>G		No	ClinGen 1000Genomes TOPMed gnomAD
CA349993970 rs1428348912	270	L>V		No	ClinGen gnomAD
rs570076014 CA62948566	272	M>I		No	ClinGen 1000Genomes
rs368280071 CA62948567	272	M>T		No	ClinGen ESP TOPMed
rs1413959671 CA349993951	273	W>*		No	ClinGen gnomAD
rs779920979 CA62948565	273	W>*		No	ClinGen TOPMed gnomAD
CA62948564 rs925974180	274	M>V		No	ClinGen TOPMed gnomAD
rs1189414584 CA349993937	275	L>M		No	ClinGen TOPMed gnomAD
rs1392291230 CA349993932	276	R>*		No	ClinGen TOPMed gnomAD
rs1167225677 CA349993931	276	R>Q		No	ClinGen TOPMed gnomAD
rs1423514253 CA349993926	277	L>F		No	ClinGen TOPMed gnomAD
CA349993921 rs1169218511	278	L>F		No	ClinGen gnomAD
CA349993900 rs1574295242	281	V>G		No	ClinGen Ensembl
rs775007272 CA2028674	285	A>G		No	ClinGen ExAC
CA2028673 rs554995648	286	G>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2028672 rs747556650	288	A>S		No	ClinGen ExAC TOPMed gnomAD
CA349993860 rs1450692859	288	A>V		No	ClinGen gnomAD
rs772547189 CA2028670	289	V>G		No	ClinGen ExAC gnomAD
rs1215045419 CA349993859	289	V>M		No	ClinGen gnomAD
rs1257339913 CA349993846	291	Q>*		No	ClinGen gnomAD
rs1212793195 CA349993845	291	Q>P		No	ClinGen TOPMed gnomAD
rs748517117 CA2028669	294	Y>C		No	ClinGen ExAC gnomAD
rs779316456 CA2028668	295	A>P		No	ClinGen ExAC gnomAD
rs1328226654 CA349993791	299	L>F		No	ClinGen gnomAD
rs745692404 CA62948562	301	M>I		No	ClinGen TOPMed gnomAD
rs755228946 CA2028667	303	S>F		No	ClinGen ExAC gnomAD
rs1327425271 CA349993750	305	S>N		No	ClinGen gnomAD
rs1397578117 CA349993736	307	H>R		No	ClinGen gnomAD
CA349993732 rs1574295051	308	Y>N		No	ClinGen Ensembl
rs1453371075 CA349993719	309	P>L		No	ClinGen gnomAD
CA349993711 rs1195183723	311	R>T		No	ClinGen gnomAD
rs1209925654 CA349993697	313	C>R		No	ClinGen TOPMed
CA2028665 rs780210694	315	Y>C		No	ClinGen ExAC gnomAD
CA349993669 rs1439520891	316	M>I		No	ClinGen gnomAD
rs1273383189 CA349993658	318	W>R		No	ClinGen gnomAD
rs993137964 CA62948166	319	K>I		No	ClinGen TOPMed
rs896161226 CA62948164	320	M>T		No	ClinGen TOPMed gnomAD
CA62948163 rs533247871	321	E>K		No	ClinGen 1000Genomes TOPMed gnomAD
CA2028660 rs371470092	322	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA349993612 rs1465249631	322	Q>R		No	ClinGen TOPMed
rs937780209 CA349993603	323	W>*		No	ClinGen TOPMed
rs937780209 CA62948162	323	W>C		No	ClinGen TOPMed
rs1374198722 CA349993600	324	F>L		No	ClinGen gnomAD
TCGA novel	326	S>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1574289409 CA349993566	328	E>D		No	ClinGen Ensembl
CA349993546 rs1300922170	332	K>*		No	ClinGen TOPMed
rs751336522 CA2028659	332	K>N		No	ClinGen ExAC gnomAD
rs1413488224 CA349993536	333	Y>C		No	ClinGen gnomAD
rs562591127 CA62948160	335	T>M		No	ClinGen 1000Genomes TOPMed gnomAD
CA349993497 rs1344212214	339	Y>H		No	ClinGen gnomAD
CA62948157 rs920892910	342	Q>*		No	ClinGen gnomAD
CA349993475 rs920892910	342	Q>K		No	ClinGen gnomAD
rs763832157 CA2028658	344	D>V		No	ClinGen ExAC gnomAD
CA349993223 rs1408158882	346	E>G		No	ClinGen gnomAD
CA2028657 rs200942153	347	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1259307577 CA349993210	348	N>S		No	ClinGen gnomAD
rs529384032 CA2028656	355	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA2028655 rs764817284	355	R>H		No	ClinGen ExAC gnomAD
CA62948154 rs868325644	356	R>Q		No	ClinGen gnomAD
CA2028654 rs561864691	356	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA349993158 rs1231952525	357	A>P		No	ClinGen gnomAD
CA349993151 rs1294490108	358	C>R		No	ClinGen TOPMed gnomAD
CA349993145 rs1399744963	358	C>W		No	ClinGen gnomAD
CA2028653 rs367843617	359	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA62948152 rs367843617	359	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA2028652 rs772426003	359	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1286746977 CA349993139	360	K>T		No	ClinGen gnomAD
CA2028650 rs373593274	361	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs1345199769 CA349993127	362	D>N		No	ClinGen gnomAD
rs977220987 CA62948151	366	W>*		No	ClinGen TOPMed gnomAD
rs1574289115 CA349993083	368	V>G		No	ClinGen Ensembl
rs1427699176 CA349993082	369	V>I		No	ClinGen gnomAD
rs1417144858 CA349993072	370	S>C		No	ClinGen TOPMed gnomAD
rs1417144858 CA349993073	370	S>Y		No	ClinGen TOPMed gnomAD
rs964815479 CA349993063	371	R>S		No	ClinGen TOPMed
CA349993053 rs1188435738	372	L>H		No	ClinGen TOPMed gnomAD
rs1486333341 CA349993040	373	H>P		No	ClinGen gnomAD
CA349993038 rs1486333341	373	H>R		No	ClinGen gnomAD
CA349993030 rs1211868174	374	T>P		No	ClinGen TOPMed gnomAD
rs1275320922 CA349993000	376	S>N		No	ClinGen TOPMed gnomAD
TCGA novel	378	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA349992890 rs1574287714	379	A>V		No	ClinGen Ensembl
rs914253369 CA62948052	380	D>E		No	ClinGen Ensembl
TCGA novel	380	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA349992741 rs1205637673	382	V>F		No	ClinGen gnomAD
CA349992678 rs1347662419	386	S>I		No	ClinGen gnomAD
rs1391121159 CA349992664	387	H>R		No	ClinGen gnomAD
rs1054127366 CA62948050	388	L>F		No	ClinGen Ensembl
CA349992611 rs1302234509	391	E>G		No	ClinGen gnomAD
CA2028635 rs763885127	392	E>D		No	ClinGen ExAC TOPMed gnomAD
rs764794335 CA2028632	404	G>D		No	ClinGen ExAC gnomAD
CA2028633 rs752455011	404	G>R		No	ClinGen ExAC TOPMed gnomAD
CA349992435 rs752455011	404	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1459485383 CA349992391	406	F>L		No	ClinGen TOPMed gnomAD
rs759125196 CA2028631	406	F>V		No	ClinGen ExAC gnomAD
CA349992328 rs1393184607	408	E>K		No	ClinGen gnomAD
CA2028630 rs532056658	409	E>A		No	ClinGen ExAC gnomAD
CA349992260 rs1170759491	412	F>S		No	ClinGen TOPMed gnomAD
rs765937658 CA2028629	414	P>S		No	ClinGen ExAC gnomAD
rs774928829 CA2028627	416	T>A		No	ClinGen ExAC TOPMed gnomAD

No associated diseases with A6NFY4

No regional properties for A6NFY4

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for A6NFY4

Functions

		Description
EC Number
Subcellular Localization	Nucleus inner membrane ; Multi-pass membrane protein ; Nucleoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
nuclear envelope	The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
nuclear inner membrane	The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope.

No GO annotations of molecular function

Name	Definition
No GO annotations for molecular function

No GO annotations of biological process

Name	Definition
No GO annotations for biological process

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5ZJY9	NEMP2	Nuclear envelope integral membrane protein 2	Gallus gallus (Chicken)	PR

10	20	30	40	50	60
MGPRQGRWWL	LLWLPPLATL	PVRGEAAAAA	LSVRRCKALK	EKDLIRTSES	DCYCYNQNSQ
70	80	90	100	110	120
VEWKYIWSTM	QVKITSPGLF	RIVYIAERHN	CQYPENILSF	IKCVIHNFWI	PKESNEITII
130	140	150	160	170	180
INPYRETVCF	SVEPVKKIFN	YMIHVNRNIM	DFKLFLVFVA	GVFLFFYART	LSQSPTFYYS
190	200	210	220	230	240
SGTVLGVLMT	LVFVLLLVKR	FIPKYSTFWA	LMVGCWFASV	YIVCQLMEDL	KWLWYENRIY
250	260	270	280	290	300
VLGYVLIVGF	FSFVVCYKHG	PLADDRSRSL	LMWMLRLLSL	VLVYAGVAVP	QFAYAAIILL
310	320	330	340	350	360
MSSWSLHYPL	RACSYMRWKM	EQWFTSKELV	VKYLTEDEYR	EQADAETNSA	LEELRRACRK
370	380	390	400	410
PDFPSWLVVS	RLHTPSKFAD	FVLGGSHLSP	EEISLHEEQY	GLGGAFLEEQ	LFNPSTA